中国中药杂志

2019, v.44(09) 1755-1759

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基于中药饮片质量常数等级评价方法的大川芎方优质优效研究
High quality and superior effect of Dachuanxiong Formula based on quality constant grading evaluation technology of Chinese medicine pieces

石佳;焦梦姣;邓哲;沈立;陈畅;章军;刘安;
SHI Jia;JIAO Meng-jiao;DENG Zhe;SHEN Li;CHEN Chang;ZHANG Jun;LIU An;Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences;Institute of Traditional Chinese Medicine,China National Traditional & Herbal Medicine Co.,Ltd.;

摘要(Abstract):

质量常数评价方法是一种基于传统特征与质控指标有机结合的中药饮片等级评价方法。该方法已成功应用于甘草等多种中药饮片的等级评价,在行业内产生了积极的影响。该文以大川芎方为范例,在饮片等级评价的基础上,将不同等级的川芎、天麻饮片组成优质、中等、合格3个不同"等级"的大川芎方,并采用药效学方法评价其药效强弱。结果显示:3个"等级"大川芎方的最大血管舒张率分别为(80. 3±5. 2)%,(67. 0±6. 1)%,(60. 3±6. 5)%,其药效强弱与其组成饮片川芎、天麻的等级优劣成正相关。该文首次以复方的形式揭示了中药饮片质量常数等级评价方法在客观可量化的划分饮片等级的同时,对由这些饮片所组成的中药复方药效强弱亦有重要的关联和提示作用,这对推动中药饮片行业的分级管理,实行优质优价,明确优质优效具有重要意义。
Quality constant is a kind of grading evaluation method of traditional Chinese medicine pieces based on the combination of traditional knowledge and modern quality control. This method has been successfully applied in the grading evaluation of Glycyrrizae Radix et Rhizome pieces and traditional Chinese medicine pieces,and with a positive influence in the industry. With Dachuanxiong Formula for example,different grades of Ligusticum chuanxiong and Gastrodia elata pieces formed high-quality,moderate and qualified Dachuanxiong Formula on the basis of the grading evaluation of the pieces,and the pharmacodynamics method was used to evaluate its efficacy. The results showed that the maximum vascular diastolic rates of Dachuanxiong Formula in the three grades were( 80. 3±5. 2) %,( 67. 0±6. 1) %and( 60. 3±6. 5) %,and the strength of pharmacodynamics was positively correlated with the grade of L. chuanxiong and G. elata pieces.The quality constant technique can objectively and quantitatively classify single decoctions,and has important correlations and prompts for the efficacy of traditional Chinese medicine prescriptions composed of these pieces,with important significance in promoting hierarchical management of the industry,implementing better price for high quality and defining high quality and superior effect.

关键词(KeyWords): 大川芎方;质量常数;饮片等级;川芎;天麻
Dachuanxiong Formula;quality constant;grading;Ligusticum chuanxiong;Gastrodia elata

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金项目(81703945);; 北京市科委“十病十药”研发专项(Z171100001717029)

作者(Author): 石佳;焦梦姣;邓哲;沈立;陈畅;章军;刘安;
SHI Jia;JIAO Meng-jiao;DENG Zhe;SHEN Li;CHEN Chang;ZHANG Jun;LIU An;Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences;Institute of Traditional Chinese Medicine,China National Traditional & Herbal Medicine Co.,Ltd.;

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DOI: 10.19540/j.cnki.cjcmm.20190221.007

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