中国中药杂志

2018, v.43(02) 274-280

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网络生物学在中医药研究中的应用
Application of network biology on study of traditional Chinese medicine

田赛赛;杨健;赵静;张卫东;
TIAN Sai-sai;YANG Jian;ZHAO Jing;ZHANG Wei-dong;College of Pharmacy,the Second Military Medical University;Institute of Interdisciplinary Complex Research,Shanghai University of Traditional Chinese Medicine;

摘要(Abstract):

随着人类基因组计划的完成,人们逐渐认识到生物系统的功能是通过基因、蛋白以及小分子之间的网络式相互作用完成的,同时发现复杂疾病往往是由于多个基因表达紊乱导致生物学过程失衡而产生的,这些促使了"多靶点"药物发现理念的兴起。中医药诊治疾病的特点是整体观和辨证论治;从分子水平上看,中药方剂具有多成分、多靶点的特点,从而可望为多靶点药物的开发提供借鉴。该文在6个方面阐述网络生物学在中医药研究中的应用,以期对中医药现代化研究提供一定参考。
With the completion of the human genome project,people have gradually recognized that the functions of the biological system are fulfilled through network-type interaction between genes,proteins and small molecules,while complex diseases are caused by the imbalance of biological processes due to a number of gene expression disorders. These have contributed to the rise of the concept of the " multi-target" drug discovery. Treatment and diagnosis of traditional Chinese medicine are based on holism and syndrome differentiation. At the molecular level,traditional Chinese medicine is characterized by multi-component and multi-target prescriptions,which is expected to provide a reference for the development of multi-target drugs. This paper reviews the application of network biology in traditional Chinese medicine in six aspects,in expectation to provide a reference to the modernized study of traditional Chinese medicine.

关键词(KeyWords): 复杂疾病;中医药;多靶点药物;整体观;辨证论治;网络生物学
complex diseases;traditional Chinese medicine;multi-target drug;holism;syndrome differentiation and treatment;network biology

Abstract:

Keywords:

基金项目(Foundation): 国家“重大新药创制”科技重大专项(2011ZX09307-002-03);; 国家自然科学基金项目(81230090,81520108030,21472238,61372194);; 上海市科委中药现代化专项(12401900801,13401900103,13401900101);; 上海市活性天然产物制备工程技术研究中心项目(16 DZ2280200);; 重庆市研究生教改项目(yjg152017)

作者(Author): 田赛赛;杨健;赵静;张卫东;
TIAN Sai-sai;YANG Jian;ZHAO Jing;ZHANG Wei-dong;College of Pharmacy,the Second Military Medical University;Institute of Interdisciplinary Complex Research,Shanghai University of Traditional Chinese Medicine;

Email:

DOI: 10.19540/j.cnki.cjcmm.20171027.018

参考文献(References):

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