中国中药杂志

2010, v.35(06) 790-793

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三乌芍蝎汤对类风湿关节炎患者细胞因子IL-18,TNF-α,IL-4,IL-10水平的影响
Effects of Sanwushaoxie decoction on IL-18,TNF-α,IL-4 and IL-10 in patients with rheumatoid arthritis

丁凡;张艳春;畅亦杰;
DING Fan1,ZHANG Yanchun1,CHANG Yijie2*(1.Infectious Diseases Hospital of Hulunbuir Ctiy Hailar District,Hailar 021000,China; 2.305 Hospital of PLA,Beijing 100017,China)

摘要(Abstract):

目的:探讨中药三乌芍蝎汤治疗类风湿性关节炎(RA)外周血细胞因子(CK)的变化。方法:随机选择RA病人63例,其中治疗组41例以三乌芍蝎汤1剂/每天,分2次口服。对照组22例,予雷公藤多苷20 mg/次,每天3次;2组均连续服用60 d。同时观察药物对患者外周血细胞因子IL-6,TNF-α,IL-4,IL-10的影响。结果:临床疗效、实验室指标治疗组明显高于对照(P<0.01,P<0.05);治疗组外周血4种细胞因子治疗前后自身比较,均有显著性意义(P<0.05,P<0.01)。与对照组比,治疗后IL-4,IL-10明显上调,有非常显著性意义(P<0.01)。结论:三乌芍蝎汤治疗RA,能调节外周血异常细胞因子,明显改善病人临床症状和实验室指标。
Objective: To investigate the therapeutic effects of Sanwushaoxie decoction on alternations of serum cytokines in patients with rheumatoid arthritis(RA).Method: Sixty-three(63) RA patients were selected and randomly divided into 2 groups,with the treatment group administered with Sanwushaoxie decoction,one prescription,2 times a day,while patients in the control group were given Common Threewingnut Root polyglycoside 20 mg a time,3 times a day.The treatment was lasted for 60 days.Serum concentrations of IL-6,TNF-α,IL-4,IL-10 were observed during the treatment.Result: The clinical effecacy and the experimental indexes were significantly improved in the treatment group than those did in the control group(P<0.01,P<0.05).There were significant differences of serum levels of 4 cytokines within the treatment group before and after the treatment(P<0.01,P<0.05).The serum levels of IL-4,IL-10 were significantly increased in treatment group compared with those did in the control group(P<0.01).Conclusion: Sanwushaoxie decoction is an effective agent in regulating cytokines,improving symptoms and experimental indexes in patients with RA.

关键词(KeyWords): 类风湿性关节炎(RA);三乌芍蝎汤;细胞因子(IL-6,TNF-α,IL-4,IL-10);中药
rheumatoid arthritis;Sanwushaoxie decoction;cytokines(IL-6,TNF-α,IL-4,IL-10);Chinese medicine

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作者(Authors): 丁凡;张艳春;畅亦杰;
DING Fan1,ZHANG Yanchun1,CHANG Yijie2*(1.Infectious Diseases Hospital of Hulunbuir Ctiy Hailar District,Hailar 021000,China; 2.305 Hospital of PLA,Beijing 100017,China)

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