中国中药杂志

2003, (07)

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安宫牛黄丸及其简化方的药效学比较研究
Comparative Studies on Pharmacological Effects of Angong Niuhuang Pill with Its Simplified Prescicription

叶祖光,王金华,梁爱华,薛宝云,王跃生,王智民,王岚,李春英,张静,黄宁,金蔼英
YE Zu-guang, WANG Jin-hua, LIANG Ai-hua, XUE Bao-yun, WANG Yue-sheng, WANG Zhi-min, WANG Lan, LI Chun-ying,ZHANG Jing, HUANG Ning, JIN Ai-ying (1. Institute of Chinese Materia Medica, Chinese Academy of Traditional Chinese Medicine, Beijing 100700, China; 2. China Beijing Tong Ren Tang Group co. ,L td. Beijing 100062, China)

摘要(Abstract):

目的:根据安宫牛黄丸的治疗学作用,比较研究安宫牛黄丸及其简化方(安宫牛黄丸全方仅缺朱砂和雄黄)的药效学作用,以探讨安宫牛黄丸中朱砂和雄黄对其药效作用的影响。方法:实验以伤寒菌苗致家兔发热、戊巴比妥钠诱导小鼠睡眠、NaNO_2诱导小鼠缺氧死亡、硝酸士的宁及戊四唑诱发小鼠惊厥为模型,观察比较安宫牛黄丸及其简化方的药效学作用。结果:安宫牛黄丸及其简化方有明显的解热作用;安宫牛黄丸及其简化方与戊巴比妥钠有明显的协同镇静作用;对NaNO_2诱导的小鼠缺氧死亡有明显的保护作用;安宫牛黄丸及其简化方对硝酸士的宁及成四唑诱发小鼠惊厥无明显的保护作用。结论:安宫牛黄丸及其简化方在上述药效学研究中,两者在药效学上无明显差异。
Objective: Based on the therapeutic claims of Angong Niuhuang pill, a series of pharmacodynamic experiments were designed, where pharmacological effects were investigated comparatively with its simplified prescription(realgar and cinnabar are removed from the original pill) as a parallel control in order to explore possible contribution of cinnabar and realgar to pharmacodyna-mic activities of the pill as a whole. Method: Anti-pyretic, sedative, anti-convulsive, and mice-protected effects of the pill and its simplified prescription as a control were observed, respectively, in rabbits with fever induced by typhoid bacillus, in pentobarbital sodium-induced sleeping mice, in mice with convulsion induced by strychnine, or pentylenetetrazole, and in mice with anoxia induced by NaNO2. Result: Both the pill and its simplified prescription were found to have Anti-pyretic action and protective effect against the mouse death induced by anoxia, and synergistic interaction with pentobarbital sodium in sedative activity, although neither of them was found to have any effects on the convulsion of mice. Conclusion: No significant difference between Angong Niuhuang pill and its simplified prescription was found in the above pharmacodynamic experiments.

关键词(KeyWords): 安宫牛黄丸;朱砂;雄黄;解热作用;镇静;缺氧
Angong niuhuang pill, cinnabar, realgar, anti-pyretic, sedative,anoxia

Abstract:

Keywords:

基金项目(Foundation): 国家“九五”攀登计划预选项目“中药现代化关键问题的基础研究”;; 国家科委资助项目(970211018-95-预-32)

作者(Author): 叶祖光,王金华,梁爱华,薛宝云,王跃生,王智民,王岚,李春英,张静,黄宁,金蔼英
YE Zu-guang, WANG Jin-hua, LIANG Ai-hua, XUE Bao-yun, WANG Yue-sheng, WANG Zhi-min, WANG Lan, LI Chun-ying,ZHANG Jing, HUANG Ning, JIN Ai-ying (1. Institute of Chinese Materia Medica, Chinese Academy of Traditional Chinese Medicine, Beijing 100700, China; 2. China Beijing Tong Ren Tang Group co. ,L td. Beijing 100062, China)

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