中国中药杂志

2014, v.39(10) 1811-1815

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定量指纹图谱在醒脑通络注射液氨基酸成分分析中的应用
Application of quantitative fingerprint to amino acids composition analysis of Xingnao Tongluo injection

胡军华;林夏;仲艳;李慧;吴健雄;李家春;王振中;萧伟;
HU Jun-hua;LIN Xia;ZHONG Yan;LI Hui;WU Jian-xiong;LI Jia-chun;WANG Zhen-zhong;XIAO Wei;Jiangsu Kanion Parmaceutical Co. ,Ltd.;State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process;

摘要(Abstract):

目的:采用定量指纹图谱对醒脑通络注射液成品中的氨基酸成分进行控制,以此来评价其产品的质量。方法:采用AccQ Tag柱前衍生的方法,建立醒脑通络注射液中氨基酸成分的定量指纹图谱方法,对10批醒脑通络注射液中的各氨基酸进行定量检测,并结合10批成品的相似度指标,综合评价其质量。结果:醒脑通络注射液中含有12种氨基酸,各氨基酸特征峰定量结果均一、稳定,10批成品指纹图谱相似度在0.90以上。结论:该方法准确、可行,是一种简便、有效的中药质量评价手段。
Objective: To control the quality of the product,quantitative fingerprint was used to evaluate the composition of the amino acids in the Xingnao Tongluo injection.Method:The method of the quantitative fingerprint to the amino acids composition was established through AccQ Tag precolumn derivatization.The quality was evaluated by the quantitative test of the amino acids and the similarity in ten batches.Result: The Xingnao Tongluo injection contained 12 amino acids and the contents of these amino acids were stable.All the ten batches of the samples had similarity of more than 0.90.Conclusion: The method was accurate,feasible and could be a simple and effective way to evaluate the quality of the traditional Chinese medicine.

关键词(KeyWords): 醒脑通络注射液;定量指纹图谱;AccQ Tag柱前衍生;氨基酸
Xingnao Tongluo injection;quantitative fingerprint;AccQ Tag precolumn derivatization;amino acid

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基金项目(Foundation): 国家“重大新药创制”科技重大专项(2011ZX09401-014)

作者(Author): 胡军华;林夏;仲艳;李慧;吴健雄;李家春;王振中;萧伟;
HU Jun-hua;LIN Xia;ZHONG Yan;LI Hui;WU Jian-xiong;LI Jia-chun;WANG Zhen-zhong;XIAO Wei;Jiangsu Kanion Parmaceutical Co. ,Ltd.;State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process;

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