中国中药杂志

2020, v.45(12) 2817-2826

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花姜酮抗肿瘤作用机制研究进展
Advances on anti-tumor mechanisms of zerumbone

杨红;豆荣梅;姚婷;桂道鹏;姜雪雯;李俊俊;戈福星;高小力;柴兴云;
YANG Hong;DOU Rong-mei;YAO Ting;GUI Dao-peng;JANG Xue-wen;LI Jun-jun;GE Fu-xing;GAO Xiao-li;CHAI Xing-yun;School of Chinese Materia Medica, Beijing University of Chinese Medicine;

摘要(Abstract):

花姜酮是一种蛇麻烷烯型单环倍半萜,在抗肿瘤方面显示了广泛而又独特的活性,其主要作用机制包括抑制肿瘤细胞生长与增殖、诱导肿瘤细胞凋亡、抑制肿瘤细胞迁移侵袭、抗肿瘤血管生成、调节机体免疫功能逆转肿瘤细胞多药耐药性等。对花姜酮的研究一直是天然药物和药理学领域的热点之一,随着研究的深入,对花姜酮抗肿瘤作用及其分子机制的内涵研究也不断的丰富,为此,该文对花姜酮的抗肿瘤机制做一归纳总结,为含有花姜酮的药物资源,及相应的抗肿瘤作用深入研究提供有价值的参考。
Zerumbone(ZER), one of humulane-type sesquiterpenoids, showed its unique advantage against tumor activities. The main underlying mechanisms include inhibiting the growth and proliferation of cancer cells, inducing apoptosis of cancer cells and differentiation of cancer cells, regulating immune function, inhibiting invasion and metastasis of cancer cells, and reversing multidrug resistance of cancer cells. Studies on ZER focusing its cytotoxic or anti-tumor is one of hot topic. Currently, with the increasing studies on ZER, the clarified mechanisms are getting rich. The present paper describes a summary of its anti-tumor mechanism of action and helps to provide significant reference to more in-depth research.

关键词(KeyWords): 花姜酮;抗肿瘤作用机制;蛇麻烷型倍半萜;综述
zerumbone;anti-tumor mechanisms;humulane-type sesquiterpenes;review

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金项目(81473426,81774001)

作者(Author): 杨红;豆荣梅;姚婷;桂道鹏;姜雪雯;李俊俊;戈福星;高小力;柴兴云;
YANG Hong;DOU Rong-mei;YAO Ting;GUI Dao-peng;JANG Xue-wen;LI Jun-jun;GE Fu-xing;GAO Xiao-li;CHAI Xing-yun;School of Chinese Materia Medica, Beijing University of Chinese Medicine;

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