中国中药杂志

2007, (22) 2337-2341

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代谢组学在植物代谢研究中的应用
Application of metabolomics in research of plant metabolites

淡墨;高先富;谢国祥;刘忠;赵爱华;贾伟;
DAN Mo,GAO Xian-fu,XIE Guo-xiang,LIU Zhong,ZHAO Ai-hua,JIA Wei(School of Pharmacy,Shanghai Jiao Tong University,Shanghai 200240,China)

摘要(Abstract):

代谢组学作为系统生物学的重要分支,近年来在植物研究领域受到广泛关注,并取得了重要进展。植物代谢组学目前虽然是一个并不成熟的领域,但是在研究模式植物的生理生化过程和基因改造等方面已成为最为有效的手段之一,近年在研究非模式植物方面特别是药用植物方面也取得了突破性进展。作者在总结植物代谢组学的定义和发展的基础上重点阐述了其最新应用,并提出了植物代谢组学可能的发展方向。植物代谢组学为植物研究提供了一个整体全面的分析平台,从宏观角度更加科学地理解植物生理生化过程,进而为人类所用提供了可能。许多植物代谢物是中药的活性成分,其种类和含量随品种、生长环境、采集季节以及炮制方法等因素而变化。因此,中药的质量问题主要就是植物代谢组的问题。由于环境因素、植物有效部位对中药药效(或价值)有一定影响,而代谢组学法可以有效检测这些因素,植物代谢组学为深入研究开发中药资源创造了新的研究平台。
Metabolomics,a branch of systems biology, has gained extensive attention and profound achievements in the plant.Although plant metabolomics is to be explored,it has been one of the most effective methods to study the physiological and biochemical process and gene modification in pattern plants.We herein summarized the concept,development,and application of metabolomics and prospected the potentials in the metabolite profiling for plant.Metabolomics provides an omics' methodology to elucidate the whole biological process,identify and quantify the complex components in the plant.A number of metabolites present in the plant are active components of traditional Chinese medicine,and these bioactive components are influenced by the multi-factors such as environment,species,and processing methods etc.Therefore,it is of great importance to analyze a wide spectrum of compositions with diverse chemical characteristics and varied concentration,which is the foundation to quality control,allowing the elucidation of the pharmacological effectiveness,and further exploiting of traditional Chinese medicine.

关键词(KeyWords): 代谢组学;代谢途径;系统生物学;中药;功能基因组学;蛋白质组学;转录组学
metabolomics;metabolic pathway;traditional Chinese medicine;system biology;functional genomics;proteomics;transcriptomics;medicinal plants

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作者(Author): 淡墨;高先富;谢国祥;刘忠;赵爱华;贾伟;
DAN Mo,GAO Xian-fu,XIE Guo-xiang,LIU Zhong,ZHAO Ai-hua,JIA Wei(School of Pharmacy,Shanghai Jiao Tong University,Shanghai 200240,China)

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