中国中药杂志

2020, v.45(20) 4882-4888

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基于LF-NMR/MRI的白芍润制过程水分状态及质构相关性的研究
Correlation between water state and texture during moistening of Paeoniae Radix Alba by LF-NMR/MRI

刘庆珊;何雁;曹秋芳;徐绍忠;谌瑞林;饶小勇;罗晓健;
LIU Qing-shan;HE Yan;CAO Qiu-fang;XU Shao-zhong;SHEN Rui-lin;RAO Xiao-yong;LUO Xiao-jian;Jiangxi University of Traditional Chinese Medicine;Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine;Jiangzhong Traditional Chinese Medicine Pieces Co., Ltd.;the National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine;

摘要(Abstract):

采用低场核磁共振与成像技术(LF-NMR/MRI)研究白芍润药过程中药材含水量及水分分布状态;采用质构仪研究白芍润药过程中质构特性的变化,并分析白芍不同润制时间的LF-NMR/MRI参数与质构特性、有效成分含量的相关性。结果表明,MRI技术能够直观、形象、准确表征药材的润制程度和水分迁移过程,润制程度与传统经验判断结果具有一致性。白芍润制过程水分迁移和水相状态的特点是浸泡时增加总含水量以自由水形式存在,流动性增大。在闷润时,总含水量不增加,而是药材多水部分向少水部分分布,流动性变差,最后使药材润透,此结果可以与MRI结果相互印证。白芍的自由水含量、总含水量分别与硬度、表面韧性、内部韧性、芍药内酯苷和芍药苷含量均有极的显著的负相关(P<0.01)。说明采用LF-NMR/MRI、质构仪可以较好表征润药过程特点,对研究白芍软化的"少泡多润,药透水尽"科学内涵、"看水头"传统经验的数据化表征提供了一种可行较为客观的评价手段,有利于优化软化工艺参数、科学制定操作规范、阐明中药软化的科学内涵,促进中药炮制的传承创新。
The changes of active ingredients content, moisture status and texture characteristics during the moistening of Paeoniae Radix Alba were studied by low-field NMR and imaging(LF-NMR/MRI) and texture analyzer, so as to analyze the correlation between LF-NMR parameters, texture characteristics and active ingredient content of Paeoniae Radix Alba during the moistening at diffe-rent times. The results showed that MRI technology could directly, vividly and accurately characterize the degree of moistening and the process of water migration, and the degree of moistening was consistent with the judgment results of traditional experience. The characteristics of moisture migration and moisture phase state in the moistening process of Paeoniae Radix Alba were that the total water content increased and existed in the form of free water, with an increased moisture mobility. In the case of dampening, the total water content did not increase, but the more watery part of the medicinal material was distributed to the less watery part, with a reduced fluidity. Finally, the medicinal materials were moistened, which can be mutually verified with the MRI results. The free water content and the total water content of Paeoniae Radix Alba had extremely negative correlations with hardness, surface toughness, internal toughness, Paeoniflorin and albiflorin contents(P<0.01). It showed that the use of LF-NMR/MRI and texture analyzer could better characterize the moistening process. It provides data characterization for the scientific connotation of "less soaking and more moisturizing, and the drug is completely saturated with water", and the traditional experience of "observing the water head". The feasible and objective evaluation method was helpful to optimize the softening process parameters, scientifically standardize the operating specifications, define the scienti-fic connotation of traditional Chinese medicine softening, and promote the inheritance and innovation of traditional Chinese medicine processing.

关键词(KeyWords): 润制过程;白芍;低场核磁共振;质构特性;有效成分含量
moistening process;Paeoniae Radix Alba;LF-NMR;texture characteristics;active ingredients content

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金项目(81960715);; 江西省卫计委中医药科研项目(2016A066)

作者(Author): 刘庆珊;何雁;曹秋芳;徐绍忠;谌瑞林;饶小勇;罗晓健;
LIU Qing-shan;HE Yan;CAO Qiu-fang;XU Shao-zhong;SHEN Rui-lin;RAO Xiao-yong;LUO Xiao-jian;Jiangxi University of Traditional Chinese Medicine;Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine;Jiangzhong Traditional Chinese Medicine Pieces Co., Ltd.;the National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine;

Email:

DOI: 10.19540/j.cnki.cjcmm.20200522.303

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