苏亚伦,黄聿,陈振宇
SU Ya-lun 1, HUANG Yu 2, CHEN Zhen-yu 3(1.Institute of Materia Medica, Chinese Academy of Medicai Sciences and Peking Union Medical College, Beijing 100050, China;2.Department of Physiology, The Chinese University of Hong Kong, Hong Kong, Ch ina;3.Department of Biochemistry, The Chinese University of Hong Kong, Hong Kong, China)[

• 1:中国医学科学院药物研究所
• 2:香港中文大学生理系
• 3:香港中文大学生物化学系 北京100050
• 4:香港

摘要(Abstract)：

目的 :分离鉴定甘肃黄芩丙酮提取物的抗氧化有效成分。方法 :采用色谱柱进行分离 ,以波谱及标准品方法鉴定化合物的结构。结果 :从丙酮提取物中分离得到了 5个化学成分 ,分别为千层纸素A(oroxylinA ,Ⅰ )、汉黄芩素 (wogonin ,Ⅱ )、黄芩素 (baicalein ,Ⅲ )、甘黄芩苷元 (ganhuangenin ,Ⅳ )、甘黄芩素 (ganhuangemin ,Ⅴ )。从甲醇提取物得到黄芩苷 (baicalin ,Ⅵ )。结论 :甘黄芩素 (ganhuangemin)为首次从甘肃黄芩中分离得到的二氢黄酮醇类化合物 ,黄芩素和甘黄芩苷元有较强的抗氧化活性 ,明显的高于BHT(butylatedhydroxytoluene)的抗氧化活性。
Objective: To isolatate and elucidate the an tioxidant constituents from acetone extract of Scutellaria rehderiana. Method: Chemical constituents were isolated by several column c hromatographies and their structures were elucidated on the basis of standard co mpounds and spectral analysis. Result: Five compounds, oro xylin A, wogonin, baicalein, ganhuangenin, ganhuangemin were isolated from aceto ne extract of S. rehderiana. Baicalin was obtained from methanol extract of S. rehderiana. Conclusion: Ganhuangemin was isolated f rom the plant for the first time. Baicalein and ganhuangenin have stronger antio xidant activity than that of BHT (butylated hydroxytoluene).[

关键词(KeyWords)： 甘肃黄芩;甘黄芩素;甘黄芩苷元;黄芩素;抗氧化成分
Scutellaria rehderiana; ganhuangenin; g anhuangemin; baicalein; antioxidant constituents

Abstract:

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作者(Author): 苏亚伦,黄聿,陈振宇
SU Ya-lun 1, HUANG Yu 2, CHEN Zhen-yu 3(1.Institute of Materia Medica, Chinese Academy of Medicai Sciences and Peking Union Medical College, Beijing 100050, China;2.Department of Physiology, The Chinese University of Hong Kong, Hong Kong, Ch ina;3.Department of Biochemistry, The Chinese University of Hong Kong, Hong Kong, China)[

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参考文献(References)：

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