中国中药杂志

2017, v.42(05) 830-835

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甘草饮片标准汤剂的研究
Research on Glycyrrhizeae Radix standard decoction

林伟雄;乐智勇;车海燕;刘荫贞;刘冲;王晖;
LIN Wei-xiong;LE Zhi-yong;CHE Hai-yan;LIU Yin-zhen;LIU Chong;WANG Hui;Guangdong Pharmaceutical University;Kangmei Pharmaceutical Research Institute Co.,Ltd.;

摘要(Abstract):

制备了15批不同产地的甘草饮片标准汤剂,对甘草苷和甘草酸进行含量测定,计算转移率与出膏率,并建立了HPLC指纹图谱分析方法。通过对15批甘草饮片标准汤剂进行测定,甘草苷和甘草酸转移率范围分别为59.4%~87.4%和49.8%~78.9%,出膏率范围为29.9%~38.9%,并用中药色谱指纹图谱相似度评价系统(2012A)软件进行指纹图谱分析,确定了10个共有峰,对15批甘草饮片标准汤剂分别进行了相似度评价,其相似度均大于0.9。该研究中甘草饮片标准汤剂制备方法规范,15批样品质量稳定,指纹图谱相似度高,其方法精密度、稳定性和重复性良好,可为甘草配方颗粒的质量控制提供参考。
Fifteen batches of Glycyrrhizeae Radix standard decoction were prepared for determination of the content of the glycyrrhizic acid and liquiritin,then the transfer rate and the extract rate were calculated and a method was established to analyze the fingerprint by HPLC. According to the measurement of 15 batches of samples,the transfer rate of the glycyrrhizic acid and liquiritin were 59. 4%-87. 4% and 49. 8%-78. 9% with extract rate of 29. 9%-38. 9%. Moreover,10 common chromatographic peaks were determined based on their fingerprint by using similarity evaluation system for chromatographic fingerprint of traditional Chinese medicine( TCM)( 2012A). The similarity results of 15 batches of samples were analyzed and compared,and the results showed that the similarity was all higher than 0. 9. Fifteen batches of samples,prepared by a standard method,have stable quality and the high similarity. The method displayed good precision,stability and repeatability in fingerprint analysis. Therefore,this study can provide a reference for the quality control of Glycyrrhizae Radix dispensing granules.

关键词(KeyWords): 甘草;标准汤剂;HPLC;指纹图谱
Glycyrrhizae Radix;standard decoction;HPLC;fingerprint

Abstract:

Keywords:

基金项目(Foundation): 广东省战略性新兴产业区域集聚发展试点项目(2014793)

作者(Author): 林伟雄;乐智勇;车海燕;刘荫贞;刘冲;王晖;
LIN Wei-xiong;LE Zhi-yong;CHE Hai-yan;LIU Yin-zhen;LIU Chong;WANG Hui;Guangdong Pharmaceutical University;Kangmei Pharmaceutical Research Institute Co.,Ltd.;

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DOI: 10.19540/j.cnki.cjcmm.20161222.070

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