中国中药杂志

2004, (07)

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熊胆消炎胶囊中挥发油β-环糊精包合工艺的研究
Study on preparation of β-cyclodextrin inclusion complex of volatile oil in Xiongdan Xiaoyan capsules

徐雄良,张志荣,何祖兴,黄国庆,冉东
XU Xiong-liang1, ZHANG Zhi-rong1, HE Zu-xing2, HUANG Guo-qing2, RAN Dong2 (1. Laboratory of Targeting and New Drug Delivery Systems, West China School of Pharmacy, Sichuan University, Chengdu 610041, China; 2. Sichuan Jinhui Pharmaceutical Company Limited, Ziyang 641300, China)

摘要(Abstract):

目的 :研究β 环糊精包合熊胆消炎胶囊中 3味中药挥发油的制备工艺。方法 :用饱和水溶液法、研磨法、超声法对混合挥发油的包合效果进行比较 ,并用正交试验法对超声法的制备工艺进行研究。结果 :确定了超声法制备包合物的最佳工艺条件。结论 :超声法对混合挥发油的包合率高 ,包合效果佳 ,工艺简便 ,可应用于生产。
Objective: To study optimum inclusion conditions for volatile oil from three medicinal slices in Xiongdan Xiaoyan capsules. Method: Saturated water solution method (agitation method), ultrasonic method and rubbing method were studied and compared. The preparation conditions of ultrasonic method were investigated by the orthogonal test. Result: The optimum inclusion conditions of ultrasonic method were established. Conclusion: The ultrasonic method can be used for production of inclusion complex in the factory with high inclusion rate and was effectiveness. [

关键词(KeyWords): 熊胆消炎胶囊;挥发油;β-环糊精;包合物;正交试验
Xiongdan Xiaoyan capsules; volatile oil; β-cyclodextrin; inclusion complex; orthogonal test

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基金项目(Foundation): 四川省重点科技项目 ( 0 1SG0 0 8 0 1)

作者(Author): 徐雄良,张志荣,何祖兴,黄国庆,冉东
XU Xiong-liang1, ZHANG Zhi-rong1, HE Zu-xing2, HUANG Guo-qing2, RAN Dong2 (1. Laboratory of Targeting and New Drug Delivery Systems, West China School of Pharmacy, Sichuan University, Chengdu 610041, China; 2. Sichuan Jinhui Pharmaceutical Company Limited, Ziyang 641300, China)

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