中国中药杂志

1989, (09) 45-47+64

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部分中药或其成分对大鼠晶体醛糖还原酶的抑制作用
Inhibition of Aldose Reductase from Rat Lens by Some Chinese Herbs and Their Components

张家庆,周云平
Zhang Jiaqing and Zhou Yunping(Department of Endocrinology, Changhai Hospital, Second Military Medical College, Shanghai)

摘要(Abstract):

对14种中药或中药成分进行大鼠晶体醛糖还原酶(AR)抑制作用的体外筛选试验,发现甘草、黄芪、丹参、龙胆草、黄芩甙、水飞蓟宾及葛根素对AR有明显抑制作用。
Nearly 20 herds or herbal components were screened for the inhibitory effect of rat lens aldose reductase(AR) with a fluorometric assay of AR activity. Among these Glycyrrhiza uralensis, Salvia miltiorrhiza, Radix astragali, Gentiana scabra, silybin, puerarin and baicalin were found to exhibit markedly inhibitory effects on AR comparable to Sorbinil. The authors suggest that some of the Chinese herbs used in the control of diabetic complications may act through the pharmacologic action of inhibiting AR.

关键词(KeyWords): 糖尿病;醛糖还原酶;中草药
diabetes mellitus, aldose reductase, Chinese herbs

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 张家庆,周云平
Zhang Jiaqing and Zhou Yunping(Department of Endocrinology, Changhai Hospital, Second Military Medical College, Shanghai)

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