中国中药杂志

2018, v.43(03) 425-439

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雷公藤制剂安全性的循证评价研究
Evidence-based evaluation on safety of Tripterygium wilfordii preparations

冯雪;方赛男;高雨鑫;刘建平;陈薇;
FENG Xue;FANG Sai-nan;GAO Yu-xin;LIU Jian-ping;CHEN Wei;Centre for Evidence-Based Chinese Medicine,Beijing University of Chinese Medicine;Department of Sociology,Acadia University;

摘要(Abstract):

该研究旨在通过结合文献计量学研究和循证评价研究的方法,对雷公藤Tripterygium wilfordii(TW)制剂的安全性进行循证评价,为政府决策和临床应用提供TW制剂(肾毒性)的循证安全性信息,为今后中草药肾毒性评估提供方法和建议。通过系统搜索国内外相关数据库,全面搜索CNKI,SinoMed,VIP,万方,PubMed,Cochrane图书馆等6个中英文数据库,检索文献类型为TW制剂安全性的所有研究类型文献,并根据纳入和排除标准对文献进行筛选和提取。所有纳入研究的方法学质量均由国际公认的评估工具或标准进行评估,用R软件分析发病率,并根据干预类型,给药途径,用药时间和研究类型进行亚组分析。
The study was aimed to conduct an evidence-based evaluation on the safety of Tripterygium wilfordii( TW) preparations through a method combined bibliometrics research with evidence-based evaluation research,to provide evidence-based safety information of the TW preparations( nephrotoxicity) for the government decision-making and clinical application,and to provides methods and suggestions for evaluating nephrotoxicity of Chinese herbal medicine( CHM) in the future. We searched relevant databases at home and abroad systematically,and six Chinese and English databases including CNKI,Sino Med,VIP,Wan Fang,Pub Med,and Cochrane library were comprehensively searched. All types of research documents about the safety of TW preparations. Literature were screened and extracted based on inclusion and exclusion criteria. The methodology quality of all included studies were assessed by internationally recognized evaluation tools or standards. The incidence rate was analyzed by using R software. Subgroup analysis were conducted according to the type of disease treated,drug delivery way,medication time,and study types.

关键词(KeyWords): 循证评价;安全性;雷公藤
evidence-based evalutation;safety;Tripterygium wilfordii

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金青年基金项目(81603451)

作者(Author): 冯雪;方赛男;高雨鑫;刘建平;陈薇;
FENG Xue;FANG Sai-nan;GAO Yu-xin;LIU Jian-ping;CHEN Wei;Centre for Evidence-Based Chinese Medicine,Beijing University of Chinese Medicine;Department of Sociology,Acadia University;

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