中国中药杂志

2019, v.44(23) 5207-5216

[打印本页] [关闭]
本期目录(Current Issue) | 过刊浏览(Past Issue) | 高级检索(Advanced Search)

真实世界清开灵注射液治疗2147例上呼吸道感染复杂网络分析
Analysis of Qingkailing Injection in treatment of combined medication features of 2 147 cases of upper respiratory tract infection

赵世初;魏瑞丽;谢雁鸣;王连心;王群;易丹辉;
ZHAO Shi-chu;WEI Rui-li;XIE Yan-ming;WANG Lian-xin;WANG Qun;YI Dan-hui;Institute of Basic Research in Clinical Medicine,China Academy of Chinese Medical Sciences;Beijing Longfu Hospital;Beijing University of Technology;School of Statistics,Renmin University;

摘要(Abstract):

急性上呼吸道感染是常见的传染病之一,尤其老年人群易感。清开灵注射液具有清热解毒之功效,可用于外感风热时毒,适用于上呼吸道感染、病毒性感冒等。基于中国中医科学院中医临床基础医学研究所构建的来自全国16家大型三级甲等医院信息系统的医疗电子数据仓库中的2 147例使用清开灵注射液的上呼吸道感染患者,采用描述分析、Apriori算法建立模型以及复杂网络分析方法,分析清开灵注射液治疗上呼吸道感染的临床特征和联合用药规律,为临床诊疗特征的挖掘及优效方案和路径的构建提供借鉴。2 147例使用清开灵注射液的上呼吸道感染患者以45岁以上中老年人居多,往往合并高血压、缺血性脑血管病、冠心病、糖尿病等;治疗上与激素类、解热镇痛药、抗生素类、营养支持剂、镇咳化痰平喘药,以及中药解表剂、理血剂联合使用较为常见。临床联合2种西药时,最常联用氯化钾注射液+头孢注射液组合(支持度33. 2%);联合2种中药时,最常联用双黄连注射液+感冒清热颗粒组合(支持度9. 13%);通过复杂网络群组模块计算,发现清开灵注射液常与抗生素类、解热镇痛药、镇咳化痰平喘药、抗病毒药、抗感染药、营养支持剂、支气管扩张剂、免疫调节剂等化药联用,并常与解表剂、祛痰剂、清热剂、开窍剂、祛风剂、补益剂、理气剂等中药联用,这可能既与上呼吸道感染对症治疗相关,又与中老年患者基础疾病相关,具有"病证结合、方证相应"的理论特色。基于真实世界大数据复杂网络群组模块挖掘获得的结果为临床优效方案和路径构建提供线索,为进一步因果研究提供信号和思路。
Acute upper respiratory infection is one of the common infectious diseases,especially in the elderly people. Qingkailing Injection has the effect of clearing away heat and detoxifying. It can be used for external wind heat,upper respiratory tract infection,viral cold,etc. Based on 2 147 cases of upper respiratory tract infection patients using Qingkailing Injection in the medical electronic data warehouse of the information system of 16 large class-A hospitals constructed by the Institute of Basic Research in Clinical Medicine,China Academy of Chinese Medical Sciences,description analysis,Apriori calculation and recurrent network analysis were used to analyze the effect of Qingkailing Injection on upper respiratory tract infection. The clinical characteristics and the law of combined use of drugs can provide reference for the mining of clinical diagnosis and treatment characteristics and the construction of optimal and effective programs and paths. 2 147 patients with upper respiratory tract infection who used Qingkailing Injection were mostly middle-aged and elderly people over 45 years old,often combined with hypertension,ischemic cerebrovascular disease,coronary heart disease,diabetes,etc.; in treatment,it was more common to use Qingkailing Injection in combination with hormones,antipyretics and analgesics,antibiotics,nutritional support agents,antitussive,expectorant and antiasthmatic drugs,as well as traditional Chinese medicine Jiebiao agents and blood management agents. The combination of potassium chloride injection and cephalosporin injection is the most commonly used in combination with two kinds of Western medicine( 33. 2%); the combination of Shuanghuanglian and Ganmao Qingre Granules is the most commonly used in combination with two kinds of traditional Chinese medicine( 9. 13%); through the calculation of complex network group module,it is found that Qingkailing Injection is often associated with antibiotics,antipyretic and analgesic drugs,antitussive,expectorant and antiasthmatic drugs,antiviral drugs and anti infection drugs. Drugs,nutritional support agents,bronchodilators,immunomodulators and other chemical drugs are often used in combination with Chinese medicine,such as Jiebiao agents,expectorants,Qingre agents,resuscitation agents,Qufeng agents,tonics,Liqi agents,which may be related to both the treatment of upper respiratory tract infection and the basic diseases of middle-aged and elderly patients,with the theoretical characteristics of " combination of disease and syndrome,corresponding formula and syndrome". Based on the real world big data complex network group module mining results provide clues for the clinical optimization scheme and path construction,and provide signals and ideas for further causal research.

关键词(KeyWords): 真实世界;清开灵注射液;上呼吸道感染;复杂网络;群组模块
HIS;Qingkailing Injection;upper respiratory tract infection;complex network;group module

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金面上项目(81973982,81473798);; 中国中医科学院中央级公益性科研院所基本科研业务费专项(Z0546);; 国家重点研发计划项目(2018YFC1707400)

作者(Author): 赵世初;魏瑞丽;谢雁鸣;王连心;王群;易丹辉;
ZHAO Shi-chu;WEI Rui-li;XIE Yan-ming;WANG Lian-xin;WANG Qun;YI Dan-hui;Institute of Basic Research in Clinical Medicine,China Academy of Chinese Medical Sciences;Beijing Longfu Hospital;Beijing University of Technology;School of Statistics,Renmin University;

Email:

DOI:

参考文献(References):

扩展功能
本文信息
服务与反馈
本文关键词相关文章
本文作者相关文章
中国知网
分享