中国中药杂志

2012, v.37(12) 1775-1781

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天麻水提取物的化学成分研究
Chemical constituents from aqueous extract of Gastrodia elata

王亚男;林生;陈明华;江冰娅;郭庆兰;朱承根;王素娟;杨永春;石建功;
WANG Ya′nan,LIN Sheng,CHEN Minghua,JIANG Bingya,GUO Qinglan, ZHU Chenggen,WANG Sujuan,YANG Yongchun,SHI Jiangong(State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China)

摘要(Abstract):

通过大孔吸附树脂、MCI树脂、正相硅胶、Sephadex LH-20、制备薄层色谱和反相HPLC等多种色谱分离方法相结合,从天麻水提物中分离得到23个化合物;借助多种波谱学分析方法鉴定他们的结构为:4-羟基-3-(4-羟基苄基)苄基甲醚(1),4-(甲氧甲基)苯基-1-O-β-D-吡喃葡萄糖苷(2),4-羟基-3-(4-羟基苄基)苯甲醛(3),4-(4-羟基苄基)-2-甲氧基苯酚(4),4,4'-亚甲基双(2-甲氧基苯酚)(5),L-苯基乳酸(6),3-甲氧基-4-羟基苄基乙醚(7),对羟基苯甲醇(8),对羟基苄基甲醚(9),对羟基苄基乙醚(10),对羟基苯甲醛(11),对羟基苯甲酸(12),对甲氧基苯甲酸(13),天麻素(14),4-(乙氧甲基)苯基-1-O-β-D-吡喃葡萄糖苷(15),对醛基苯基-1-O-β-D-吡喃葡萄糖苷(16),对甲苯基-1-O-β-D-吡喃葡萄糖苷(17),甲基-O-β-D-吡喃葡萄糖苷(18),5-羟甲基糠醛(19),派立辛(20),派立辛B(21),派立辛C(22)和薯蓣皂苷元(23)。其中化合物1和2为新化合物,化合物3~7,18和23为首次从该属植物中分离得到,并首次报道化合物4的碳谱数据。
Two new compounds(1 and 2),together with twenty-one known compounds(3-23),were isolated by a combination of various chromatographic techniques including column chromatography over macroporous resin,MCI gel,silica gel,and Sephadex LH-20 and reversed-phase HPLC.Their structures were identified by spectroscopic data analysis as 4-hydroxy-3-(4-hydroxybenzyl)benzyl methyl ether(1),4-(methoxymethyl) phenyl-1-O-β-D-glucopyranoside(2),hibicutaiwanin(3),4-(4-hydroxybenzyl)-2-methoxyphenol(4),4,4′-methylenebis(2-methoxyphenol)(5),L-phenyllactic acid(6),4-hydroxy-3-methoxybenzyl ethol ether(7),p-hydroxylbenzyl alcohol(8),p-hydroxylbenzyl methyl ether(9),p-hydroxylbenzyl ethyl ether(10),p-hydroxybenzaldehyde(11),p-hydroxybenzoic acid(12),p-hydroxybenzoic acid(13),gastrodin(14),4-(ethoxymethyl) phenyl-1-O-β-D-glucopyranoside(15),4-(β-D-glucopyranosyloxy)benzaldehyde(16),p-methylphenyl-1-O-β-D-glucopyranoside(17),methyl-O-β-D-glucopyranoside(18),5-hydroxymethl-furan aldehyde(19),parishin(20),parishin B(21),parishin C(22),and diosgenin(23).The 13C-NMR data of compound 4 was first reported.

关键词(KeyWords): 天麻;水提物;化学成分;4-羟基-3-(4-羟基苄基)苄基甲醚;4-(甲氧甲基)苯基-1-O-β-D-吡喃葡萄糖苷
Gastrodia elata;aqueous extract;chemical constituents;4-hydroxy-3-(4-hydroxybenzyl)benzyl methyl ether;4-(methoxymethyl) phenyl-1-O-β-D-glucopyranoside

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金项目(30825044,20932007);; 国家“重大新药创制”科技重大专项(2011ZX09307-002-01)

作者(Author): 王亚男;林生;陈明华;江冰娅;郭庆兰;朱承根;王素娟;杨永春;石建功;
WANG Ya′nan,LIN Sheng,CHEN Minghua,JIANG Bingya,GUO Qinglan, ZHU Chenggen,WANG Sujuan,YANG Yongchun,SHI Jiangong(State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China)

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