中国中药杂志

2004, (12)

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不同粒径血竭粉末与制剂滴丸止血作用比较研究
Comparative study of effects of xuejie superfine ponders with different diameters and its drop on stopping bleeding

胡海燕,黎颖,杨得坡,王冬梅,朱小南,陈汝筑,何振辉
HU Hai yan 1, LI Ying 1, YANG De po 1, WANG Dong mei 1, ZHU Xiao nan 2, CHEN Ru zhu 2, HE Zhen hui 3 (1 School of pharmaceutical sciences, SUN Yat sen University, Guangzhou 510080, China; (2 School of medical sciences, SUN Yat sen Uviversity Guangzhou 510080,China; (3 Research Center of Nanometer Technology, Sun Yat sen University, Guangzhou 510275, China)

摘要(Abstract):

目的 :比较血竭滴丸、不同粒径血竭粉末的止血作用 ,即考察增加比表面积或 (和 )增加亲水性对血竭药理作用的影响。方法 :采用小鼠血浆复钙时间试验、小鼠凝血时间试验、小鼠断尾出血时间试验。结果 :各血竭药物组与空白组比较差异均有统计学意义 (P <0 0 1,P <0 0 0 1) ;除小鼠凝血试验血竭滴丸组与粗粉组比较差异无统计学意义外 (P >0 0 5 ) ,血竭超微粉Ⅱ组和滴丸组与粗粉组比较差异均有统计学意义 (P <0 0 5 ,P <0 0 1)。结论 :将血竭制成超微粉及制成滴丸可以显著增强血竭的止血作用。
Objective: To compare the effects of xuejie superfine ponders with different diameters and its drop on stopping bleeding Method: Plasma recalcification time test, coagulation time test, bleeding time test were adopted Result: Compared with control group,all drug containing groups showed remarkable difference on stopping bleeding in the all tests Both group super fine powder Ⅱand group drop pill showed remarkable difference on stopping bleeding compared with group conventional powder except for group drop pill in the coagulation time test Conclusion: Super fine powder of Xuejie S draconis and its drop pill can enhance its pharmacological action

关键词(KeyWords): 血竭;超微粉;滴丸;止血作用
Xuejie(Sanguis draconis); super fine powder; drop pill; stopping bleeding

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基金项目(Foundation): 广州市科技局 2 0 0 1年重点项目资助 (0 10 44 815 9)

作者(Author): 胡海燕,黎颖,杨得坡,王冬梅,朱小南,陈汝筑,何振辉
HU Hai yan 1, LI Ying 1, YANG De po 1, WANG Dong mei 1, ZHU Xiao nan 2, CHEN Ru zhu 2, HE Zhen hui 3 (1 School of pharmaceutical sciences, SUN Yat sen University, Guangzhou 510080, China; (2 School of medical sciences, SUN Yat sen Uviversity Guangzhou 510080,China; (3 Research Center of Nanometer Technology, Sun Yat sen University, Guangzhou 510275, China)

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