中国中药杂志

2021, v.46(06) 1357-1367

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中药材生长年限鉴定方法的研究进展
Research progress on identification methods of growth years of traditional Chinese medicinal materials

陈泽炎;赖长江生;魏旭雅;宫丽;邱子栋;
CHEN Ze-yan;LAI Chang-jiang-sheng;WEI Xu-ya;GONG Li;QIU Zi-dong;State Key Laboratory Breeding Base of Dao-di Herbs,National Resource Center for Chinese Materia Medica,China Academy of Chinese Medical Sciences;

摘要(Abstract):

中药材的生长年限与质量关系密切,直接影响临床用药的疗效和安全,所以建立中药材生长年限鉴定方法尤为重要。该文主要对中药材生长年限的鉴定方法进行了系统总结,依据鉴定的原理和方法主要分为传统鉴定、分子鉴定、理化鉴定及综合鉴定4类方法。依靠丰富的传统经验、客观的分子鉴定标记和多样的理化鉴定方法及综合鉴定技术(包括红外光谱、核磁共振波谱、高效液相色谱、气相色谱、质谱、仿生识别技术及它们的串联技术等)深入比较性状或化学指纹的差异,依次从外观性状、整体的指纹信息或特定的化学指标含量及指标间的比例关系快速鉴定或者预测中药材的生长年限。拟通过成熟品种的案例分析推动建立完善的中药材生长年限鉴定技术体系,以期为其他多年生中药材生长年限的鉴定提供借鉴方案,保障中药材的质量精准控制。
The growth years of traditional Chinese medicinal materials are closely related to their quality, which directly affects the efficacy and safety of clinical medication. Therefore, it is particularly important to establish an identification method for the growth years of traditional Chinese medicinal materials. In this review, the identification methods for the growth years of traditional Chinese medicinal materials were summarized systematically, and were divided into four types according to the identification principles and methods: traditional identification, molecular identification, physical/chemical identification, and integrated identification. Relying on rich experience, objective molecular markers, various physical/chemical methods and integrated identification techniques(including infrared spectroscopy, nuclear magnetic resonance spectroscopy, high performance liquid chromatography, gas chromatography, mass spectrometry, bionic identification technology and their tandem technologies, etc.), the differences of characters or chemical fingerprints were compared in depth. The growth years of traditional Chinese medicinal materials were quickly identified or predicted by the appearance and characters, the whole fingerprint information or the content of specific chemical markers, and their content ratios. Through the case analysis of mature varieties, we intend to promote the establishment of a perfect technology system for the identification of the growth years of traditional Chinese medicinal materials, and to provide a reference for other perennial herbal materials, finally resulting in the accurate and precise quality control of traditional Chinese medicinal materials.

关键词(KeyWords): 中药材;生长年限;高效液相色谱;气相色谱;质谱;红外光谱
traditional Chinese medicinal materials;growth years;high performance liquid chromatography;gas chromatography;mass spectrometry;infrared spectroscopy

Abstract:

Keywords:

基金项目(Foundation): 国家重点研发计划项目(2018YFC1706104);; 中国科协青年人才托举工程(CAST-2018-QNRC1-04);; 中央级公益性科研院所基本科研业务费专项(ZZ13-YQ-090);; 中央本级重大增减支项目(2060302)

作者(Author): 陈泽炎;赖长江生;魏旭雅;宫丽;邱子栋;
CHEN Ze-yan;LAI Chang-jiang-sheng;WEI Xu-ya;GONG Li;QIU Zi-dong;State Key Laboratory Breeding Base of Dao-di Herbs,National Resource Center for Chinese Materia Medica,China Academy of Chinese Medical Sciences;

Email:

DOI: 10.19540/j.cnki.cjcmm.20201223.102

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