中国中药杂志

2021, v.46(20) 5194-5200

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天南星化学成分及生物活性研究进展
Research progress on chemical constituents and biological activities of Arisaematis Rhizoma

孙娜;刘佳艺;于婉莹;刘素素;任玉龙;方凯兴;舒朋华;
SUN Na;LIU Jia-yi;YU Wan-ying;LIU Su-su;REN Yu-long;FANG Kai-xing;SHU Peng-hua;School of Food and Pharmacy, Xuchang University;

摘要(Abstract):

《中国药典》收载的中药材天南星是天南星科天南星属植物天南星、异叶天南星或东北天南星的干燥块茎。该论文主要对药典中收载的该药材的上述3个品种中近年来报道的化学成分及其结构进行了分类总结,包括生物碱类、黄酮类、苯丙素、木脂素及苯环衍生物、甾体和萜类、苷类和酯类等,并对这些化学成分报道的相关生物活性包括细胞毒活性、抗肿瘤活性、抗菌活性、杀线虫活性等进行了综述。尽管关于中药天南星化学成分的综述已有相关报道,但是关于化学成分的结构及其分类还不够清晰,该综述为后期对中药材天南星的化学成分研究尤其是化学结构鉴定提供依据,同时目前多数关于天南星生物活性的综述主要是针对粗提物,该论文主要针对相关单体化合物的生物活性进行了总结,为后期从该药材中开发新颖高效低毒的活性先导化合物奠定了基础。
Arisaematis Rhizoma included in the Chinese Pharmacopoeia is the dried tuber of Arisaema erubescens, A. heterophyllum or A. amurense in the family Araceae. This paper mainly focuses on the classification and summary of the chemical components and structures reported in recent years in the above three varieties of this medicinal material included in the pharmacopoeia, including alkaloids, flavonoids, phenylpropanoids, lignans and benzene ring derivatives, steroids and terpenes, glycosides and esters, etc. Then we reviewed the reported biological activities of these chemical components, including cytotoxicity, antitumor activity, antibacterial activity, nematicidal activity, etc. Although there have been reports on the review of the chemical composition of the medicinal material, the structure and classification of the chemical composition in these reviews are not clear enough. This review provides a basis for the later study of the chemical composition of this medicinal material, especially the identification of the chemical structures. And most of the current reviews on the biological activity of this medicinal material are mainly for the crude extract. This paper mainly summarized the biological activity of related monomer compounds and expected to lay a foundation for the development of novel high-efficiency and low-toxicity active leading compounds from Arisaematis Rhizoma.

关键词(KeyWords): 天南星;异叶天南星;东北天南星;化学成分;生物活性
Arisaema erubescens;A.heterophyllum;A.amurense;chemical constituents;biological activity

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金青年基金项目(21702178);; 国家大学生创新创业项目(2020010480003);; 许昌学院校级科研项目(2020ZD002)

作者(Author): 孙娜;刘佳艺;于婉莹;刘素素;任玉龙;方凯兴;舒朋华;
SUN Na;LIU Jia-yi;YU Wan-ying;LIU Su-su;REN Yu-long;FANG Kai-xing;SHU Peng-hua;School of Food and Pharmacy, Xuchang University;

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