中国中药杂志

2021, v.46(20) 5304-5309

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水鬼蕉中的非生物碱类成分
Non-alkaloid constituents of Hymenocallis littoralis

段志文;张洁;陈晓娟;庞旭;马百平;
DUAN Zhi-wen;ZHANG Jie;CHEN Xiao-juan;PANG Xu;MA Bai-ping;Institute of Radiation Medicine, Academy of Military Medical Sciences, Academy of Military Science;Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine;

摘要(Abstract):

水鬼蕉Hymenocallis littoralis为石蒜科多年生草本植物,具有抗肿瘤、抗病毒及抗炎等多种药理活性。生物碱作为其代表性化学成分一直以来受到诸多关注,而其他类成分报道较少。水鬼蕉中非生物碱成分的化学组成如何值得探究。鉴于此,该文运用多种色谱分离方法并利用波谱学技术,从水鬼蕉干燥全草的95%乙醇提取物中共分离得到13个非生物碱单体化合物,分别为5,7-dihydroxy-6,8-dimethoxy-2-hydroxymethyl-4H-chromen-4-one(1)、undulatoside A(2)、(2S)-7,4′-dihydroxyflavane(3)、柚皮素(4)、4′,7-hydroxy-8-methylflavanone(5)、8-methylnaringenin(6)、8-去甲杜鹃素(7)、6-methyl-aromadendrin(8)、4′,5,7-三羟基-8-甲基黄烷酮(9)、syzalterin(10)、6-methylapigenin(11)、异甘草酸(12)和undatuside C(13)。其中,化合物1为1个新色原酮衍生物,化合物2和4~13均为首次从该植物中分离得到。
Perennial herb Hymenocallis littoralis(Amaryllidaceae) boasts anti-tumor, anti-virus, and anti-inflammatory activities. As the representative constituents, alkaloids have attracted much attention, whereas the non-alkaloid constituents have been rarely reported. Therefore, this study investigated the non-alkaloid constituents of H. littoralis and their contribution to the various pharmacological activities of the herb. Thirteen non-alkaloid compounds were isolated from the 95% ethanol extract of dried whole plant of H. littoralis after a series of chromatographic separation steps and spectral analysis, and they were identified as 5,7-dihydroxy-6,8-dimethoxy-2-hydroxymethyl-4H-chromoen-4-one(1), undulatoside A(2),(2S)-7,4′-dihydroxyflavane(3), naringenin(4), 4′,7-hydroxy-8-methylflavanone(5), 8-methylnaringenin(6), 8-demethylfarrerol(7), 6-methyl-aromadendrin(8), 4′,5,7-trihydroxy-8-methylflavanone(9), syzalterin(10), 6-methylapigenin(11), isoliquiritigenin(12), and undatuside C(13) based on the spectroscopic data analysis. Among them, compound 1 was a new chromone derivative, and compounds 2 and 4-13 were isolated form this plant for the first time.

关键词(KeyWords): 石蒜科;水鬼蕉;非生物碱类成分;分离;结构鉴定
Amarylliaceae;Hymenocallis littoralis;non-alkaloid constituents;isolation;structural identification

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基金项目(Foundation): 国家自然科学基金项目(81803385);; 中国博士后科学基金项目(2019M653957)

作者(Author): 段志文;张洁;陈晓娟;庞旭;马百平;
DUAN Zhi-wen;ZHANG Jie;CHEN Xiao-juan;PANG Xu;MA Bai-ping;Institute of Radiation Medicine, Academy of Military Medical Sciences, Academy of Military Science;Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine;

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