中国中药杂志

2021, v.46(06) 1430-1437

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荸荠中苯丙素类化学成分及其保肝活性研究
Studies on phenylpropanoids from Eleocharis dulcis and their hepatoprotective activities

魏荣锐;马勤阁;桑志培;董江红;
WEI Rong-rui;MA Qin-ge;SANG Zhi-pei;DONG Jiang-hong;Key Laboratory of Modern Preparation of Traditional Chinese Medicine of Ministry of Education & Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine,Jiangxi University of Traditional Chinese Medicine;College of Chemistry and Pharmaceutical Engineering,Nanyang Normal University;College of Chemistry and Pharmaceutical Engineering,Huanghuai University;

摘要(Abstract):

研究荸荠Heleocharis dulcis中苯丙素类化学成分及其保肝活性。采用柱色谱和制备液相色谱等方法对荸荠乙酸乙酯部位进行分离纯化,通过各种波谱技术对所得单体化合物进行结构鉴定。利用APAP诱导的肝细胞HL-7702损伤模型,对所得化合物进行保肝活性筛选和评价。从荸荠乙酸乙酯部位中分离得到16个化合物,分别鉴定为:6′-(4″-羟基3″-甲氧基-苯丙烯酮基)-1-(10-甲氧基-苯丙酮基)-1′-O-β-D-吡喃葡萄糖苷(1),susaroyside A(2), clausenaglycoside B(3),clausenaglycoside C(4),clausenaglycoside D(5), emarginone A(6),emarginone B(7),thoreliin B(8),4-O-(1′,3′-dihydroxypropan-2′-yl)-dihydro-coniferyl alcohol 9-O-β-D-glucopyranoside (9),2-[4-(3-methoxy-1-propenyl)-2-methoxy-phenoxy]-propane-1,3-diol(10), 6′-O-(E-cinnamoyl)-coniferin (11),methyl 3-(2-O-β-D-glucopyranosyl-3,4,5,6-tetramethoxyphenyl) propanoate (12), clausenaglycoside A (13),9-O-(E-cinnamoyl)-coniferin (14), 6′-O-(E-cinnamoyl)-syringin (15), 2′-O-(E-cinnamoyl)-syringin (16)。化合物1为新化合物,化合物2~16为首次从本植物中分离所得。其中,化合物2和8具有一定的保肝活性。
To study phenylpropanoids from Eleocharis dulcis and their hepatoprotective activities. The compounds were separated and purified from ethyl acetate part by conventional column chromatography and preparative liquid chromatography, and their structures were identified by various spectral techniques. The HL-7702 cells damage model of hepatocytes induced by APAP was used to screen and evaluate the hepatoprotective activities of these compounds. Sixteen compounds were isolated from ethyl acetate part of E. dulcis, and their structures were identified as 6′-(4″-hydroxy-3″-methoxy-phenylpropenyl)-1-(10-methoxy-phenylacetone)-1′-O-β-D-glucopy-ranoside(1), susaroyside A(2), clausenaglycoside B(3), clausenaglycoside C(4), clausenaglycoside D(5), emarginone A(6), emarginone B(7), thoreliin B(8), 4-O-(1′,3′-dihydroxypropan-2′-yl)-dihydroconiferyl alcohol 9-O-β-D-glucopyranoside(9), 2-[4-(3-methoxy-1-propenyl)-2-methoxy-phenoxy]-propane-1,3-diol(10), 6′-O-(E-cinnamoyl)-coniferin(11), methyl 3-(2-O-β-D-glucopyranosyl-3,4,5,6-tetramethoxyphenyl) propanoate(12), clausenaglycoside A(13), 9-O-(E-cinnamoyl)-coniferin(14), 6′-O-(E-cinnamoyl)-syringin(15), 2′-O-(E-cinnamoyl)-syringin(16). Among them, compound 1 was a new compound. Compounds 2-16 were isolated from this plant for the first time. Among them, compounds 2 and 8 showed certain hepatoprotective activities.

关键词(KeyWords): 荸荠;苯丙素;保肝活性
Heleocharis dulcis;phenylpropanoid;hepatoprotective activity

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金项目(81803843);; 江西省中医药管理局科技计划项目(2019A002,2019A018);; 江西省教育厅科技项目(GJJ180662,GJJ180688);; 江西省卫生和计划生育委员会科研项目(20195648,20195650);; 江西省中药学一流学科专项科研基金项目(JXSYLXK-ZHYAO027,JXSYLXK-ZHYAO032)

作者(Author): 魏荣锐;马勤阁;桑志培;董江红;
WEI Rong-rui;MA Qin-ge;SANG Zhi-pei;DONG Jiang-hong;Key Laboratory of Modern Preparation of Traditional Chinese Medicine of Ministry of Education & Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine,Jiangxi University of Traditional Chinese Medicine;College of Chemistry and Pharmaceutical Engineering,Nanyang Normal University;College of Chemistry and Pharmaceutical Engineering,Huanghuai University;

Email:

DOI: 10.19540/j.cnki.cjcmm.20200821.201

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