中国中药杂志

2019, v.44(15) 3275-3280

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质量常数方法应用于川芎饮片等级评价研究
Application of quality constant method in evaluation of Ligusticum chuanxiong pieces

石佳;沈立;邓哲;赵桉熠;吕慧芳;陈畅;刘安;
SHI Jia;SHEN Li;DENG Zhe;ZHAO An-yi;LYU Hui-fang;CHEN Chang;LIU An;Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences;Jiangxi University of Traditional Chinese Medicine;China National Traditional Chinese Medicine Co.Ltd.;

摘要(Abstract):

将顶刀片模型质量常数中药饮片质量等级划分方法应用于川芎饮片的等级评价中,建立合理的川芎饮片等级标准。旨在将传统等级划分优势与现代质控指标相结合,通过测量从其道地产区以及多个药材市场所收集的不同厂家不同批号的15批川芎饮片样品的自然形态参数、切制工艺参数、以及HPLC检测其重要活性成分阿魏酸的内在含量,综合以上数据并计算、分析其质量常数以及百分质量常数,对该15批川芎饮片样品进行等级划分。结果显示所收集的15批川芎饮片样品的质量常数为0. 53~3. 00;若以百分质量常数≥80%为一等饮片,50%~80%为二等饮片,剩余为三等饮片,评定结果如下:一等川芎饮片质量常数≥2. 40,二等川芎饮片质量常数应为1. 70~2. 40,三等川芎饮片质量常数<1. 70。该文工作将顶刀片模型质量常数饮片等级划分方法进一步应用与实践,证明该方法的科学性、合理性、多适应性,同时丰富了川芎饮片等级评价的研究数据,为川芎饮片等级评价的推广提供了有益的参考,也为课题组下一步研究奠定实验基础。
The method of classifying the quality grade of traditional Chinese medicine slices with cross section model quality constant was applied to the grade evaluation of Ligusticum chuanxiong pieces,and a reasonable grade standard of L. chuanxiong pieces was established. The purpose is to classify the 15 batches of L. chuanxiong pieces by combining the advantages of traditional grading with modern quality control indicators. By measuring the natural morphological parameters,processing parameters and the intrinsic content of ferulic acid,an important active ingredient,of the 15 batches of L. chuanxiong pieces collected from different manufacturers and different batches of different medicinal materials markets,we can synthesize the results. The mass constants and percentage mass constants are calculated and analyzed based on the above data. The results showed that the quality constants of 15 batches of L. chuanxiong pieces collected ranged from 0.53-3.00; if the percentage mass constants were more than 80%,50%-80% was second-class pieces,and the rest were third-class pieces,the evaluation results were as follows: the quality constants of first-class L. chuanxiong pieces were more than 2.40,the quality constants of second-class L. chuanxiong pieces should be 1.70-2.40,and the quality constants of third-class L. chuanxiong pieces should be less than 1.70. In this paper,the method of dividing the quality constants of the top blade model into different grades is further applied and practiced,which proves that the method is scientific,reasonable and multi-adaptable. At the same time,it enriches the research data of the grade evaluation of L. chuanxiong pieces,provides a useful reference for the promotion of the grade evaluation of L. chuanxiong pieces,and lays an experimental foundation for the next research of the subject group.

关键词(KeyWords): 质量常数;饮片等级;川芎;阿魏酸
quality constant;grades evaluation;Ligusticum chuanxiong;ferulic acid

Abstract:

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基金项目(Foundation): 北京市科委“十病十药”研发专项(Z171100001717029)

作者(Author): 石佳;沈立;邓哲;赵桉熠;吕慧芳;陈畅;刘安;
SHI Jia;SHEN Li;DENG Zhe;ZHAO An-yi;LYU Hui-fang;CHEN Chang;LIU An;Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences;Jiangxi University of Traditional Chinese Medicine;China National Traditional Chinese Medicine Co.Ltd.;

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