中国中药杂志

2015, v.40(12) 2340-2344

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熟地黄提取物制备工艺研究
Purification technology of manninotirose in Rehmanniae Radix Praeparata by D-101 microporous adsorption resin

王星星;钱俊;吴云;颜丙鹏;王振中;萧伟;
WANG Xing-xing;QIAN Jun;WU Yun;YAN Bing-peng;WANG Zhen-zhong;XIAO Wei;Jiangsu Kanion Pharmaceutical Co. ,Ltd.;State Key Laboratory of New-Tech for Chinese Medicine Pharmaceutical Process;

摘要(Abstract):

优选熟地黄提取物的大孔树脂纯化工艺。以甘露三糖质量浓度为指标,考察D-101大孔吸附树脂纯化熟地黄的吸附流量、时间和洗脱剂的种类、用量、流量等。D-101型大孔吸附树脂的最佳工艺为上样甘露三糖质量浓度161.16~53.72 mg·g-1,吸附流量1.5 m L·min-1,吸附时间240 min,洗脱剂为纯化水,洗脱剂用量6 BV,洗脱流量1.5 BV·h-1。研究优选的工艺可以使熟地黄提取物中甘露三糖质量分数达50%以上,且中试放大效果较好。优选的工艺稳定可行。
This paper was aim to optimize the purification technology of Rehmanniae Radix Praeparata extract with macroporous adsorption resin. With the content of manninotriose as index,the absorptive flow and time were investigated,as well as kinds,amount,flow of eluent. D-101 type macroporous adsorption resin was the best choice for the purification of manninotriose. The optimized parameters were as follows: the content of manninotriose at 161. 16-53. 72 mg·g- 1,absorption time 240 min,eluting solvent of purified water,volume flow at 1. 5 BV·h- 1,and eluant volume at 6 BV. D-101 type macroporous adsorption resin could significantly increase the purity of Rehmanniae Radix Praeparata extract with the advantage of high absorption,remove most part of impurity,and the effect of semi-works production was better.

关键词(KeyWords): 熟地黄;甘露三糖;大孔吸附树脂;纯化
Rehmanniae Radix Praeparata;manninotriose;macroporous adsorption resin;purification technology

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作者(Author): 王星星;钱俊;吴云;颜丙鹏;王振中;萧伟;
WANG Xing-xing;QIAN Jun;WU Yun;YAN Bing-peng;WANG Zhen-zhong;XIAO Wei;Jiangsu Kanion Pharmaceutical Co. ,Ltd.;State Key Laboratory of New-Tech for Chinese Medicine Pharmaceutical Process;

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