中国中药杂志

2009, v.34(06) 690-693

[打印本页] [关闭]
本期目录(Current Issue) | 过刊浏览(Past Issue) | 高级检索(Advanced Search)

流化床制备芪仙汤微丸的工艺研究
Study on preparation of Qixian decoction pellets in tangential spray fluid bed

罗晓健;张国松;黄锋荣;饶小勇;何雁;胡鹏翼;
LUO Xiaojian,ZHANG Guosong,HUANG Fengrong,RAO Xiaoyong,HE Yan,HU Pengyi(National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine,Nanchang 330006,China)

摘要(Abstract):

目的:制备芪仙汤中药微丸。方法:以微丸得率、粒径分布、休止角、堆密度等为指标,采用流化床侧喷制丸法,考察了影响芪仙汤微丸成型过程的处方因素和工艺因素。结果:空白丸芯制备:淀粉与糊精的比例为2∶1,黏合剂为70%的糖浆,主机转速为200 r.min-1,鼓风流量为15×20 L.min-1,喷气流量为15 L.min-1,喷气压力为0.15 Mpa,喷浆泵转速20~50 r.min-1;微丸成型的处方优化及工艺参数:浸膏质量浓度1.12~1.15 g.mL-1,稀释剂选用微晶纤维素,用量为8%,喷液流量10~12 mL.min-1,转盘频率18~20 Hz,风机频率22 Hz,滚圆干燥时间30 min。结论:采用流化床侧喷制备的芪仙汤微丸外观光滑,圆整度较高;粒径在500~700μm的微丸得率为90.6%。
Objective:To prepare Qixian decoction pellets.Method:The formulation and technological factors influencing the preparation of Qixian decoction were investigated in tangential spray fluid bed choosing the yield of pellets,particle diameter distribution,repose angle,bulk density as inspecting indexes.Result:the technological parameters for the preparation of blank pellets were as follows:the ratio of starch and dextrin was 2∶1,the adhesive agent was 70% syrup,the rotating speed was 200 r·min-1,the air blow flow was 15×20 L·min-1,the rate of air flow was 15 L·min-1,the spay air pressure was 0.15 MPa,and the rotating rate of spray solution pump was 20-50 r·min-1;The optimized technological parameters for the preparation of Qixian decoction were as follows:the relative density of the extract was 1.12-1.15 g·min-1,the diluent was MCC and its quantity was 8%,the rotating rate of spray solution pump was 10-12 mL·min-1,the frequency of the rotor disc was 18-20 Hz,the atomizing pressure was 0.2 MPa,the frequency of the fan was 22 Hz,and the spheronisation and drying time was 30 mins.Conclusion:the appearance of the Qixian decoction pellets prepared in tangential spray fluid bed are smoothing and round,the yield of pellets are high,and pellets of the particle size between 500-700 μm is 90.6%.

关键词(KeyWords): 芪仙汤微丸;流化床;中药微丸制备工艺
Qixian decoction pellets;tangential spray fluid bed;traditional Chinese medicine pellets

Abstract:

Keywords:

基金项目(Foundation): 江西省自然科学基金项目(2007GQY0946)

作者(Author): 罗晓健;张国松;黄锋荣;饶小勇;何雁;胡鹏翼;
LUO Xiaojian,ZHANG Guosong,HUANG Fengrong,RAO Xiaoyong,HE Yan,HU Pengyi(National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine,Nanchang 330006,China)

Email:

DOI:

扩展功能
本文信息
服务与反馈
本文关键词相关文章
本文作者相关文章
中国知网
分享