中国中药杂志

2001, (04)

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天麻促智颗粒的脑保护机制研究
Protective Mechanism of Tianmacuzhi Granules in Brain

曹春雨,杜贵友,左萍萍,刘显峰,王文韬,赵雍,王秀荣,崔海峰
CAO Chun-yu1,DU Gui-you1,ZUO Ping-ping2,LIU Xian-feng3, WANG Wen-tao3,ZHAO Yong1,WANG Xiu-rong1,CUI Hai-feng1 (1. Institute of Chinese Materia Medica,China Academy of Traditional Chinese Medicine, Beijing 100700,China; 2. Department of Pharmacology,

摘要(Abstract):

目的 :探讨天麻促智颗粒 (TMC)的脑保护机制 ,为其治疗老年血管性痴呆的作用提供药理学依据。方法 :利用小鼠双侧颈总动脉结扎 再灌手术造成的学习记忆障碍动物模型 ,观察不同剂量的TMC对脑内神经递质受体 (N 甲基 D 天冬氨酸受体即NMDA受体、胆碱能M受体 )及谷胱甘肽过氧化物酶 (GPx)活性的影响。结果 :TMC可不同程度地抑制小鼠脑损伤引起的大脑皮层、海马两部位NMDA受体活性 ;增强两部位的M受体活性 ;还可增加皮层、海马和肝脏中GPx的活性。结论 :TMC治疗血管性痴呆的机制可能与其抑制脑内兴奋性氨基酸受体活性、提高胆碱能神经功能以及增加抗过氧化酶活性有关。
Objective: To provide pharmacological evidence for the protective effects of Tianmacuzhi Granules (TMC) in mouse brain in a ischemia-reperfusion model. Method: Receptor binding test of NMDA receptor and M receptor in brain, GPx activity determination in brain and liver effected by different dose of TMC were performed. Result: TMC could reduce the NMDA receptor activitiy, increase the M receptor activity and GPx activity of cerebral cortex and hippocampus tissues significantly. Conclusion: TMC might antagonize ischemia-reperfusion injury of brain by reducing the glutamate neurotoxicity and increasing the function of cholinergic nerve and effects of anti-peroxidization in brain.

关键词(KeyWords): 天麻促智颗粒;脑缺血;N-甲基-D-天冬氨酸受体;胆碱能M受体
Tianmacuzhi granules; brain injury; N-methyl-D-Aspartate receptor, cholinergic M receptor

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基金项目(Foundation): 国家科委新药基金项目!(9690 10 5 71)

作者(Author): 曹春雨,杜贵友,左萍萍,刘显峰,王文韬,赵雍,王秀荣,崔海峰
CAO Chun-yu1,DU Gui-you1,ZUO Ping-ping2,LIU Xian-feng3, WANG Wen-tao3,ZHAO Yong1,WANG Xiu-rong1,CUI Hai-feng1 (1. Institute of Chinese Materia Medica,China Academy of Traditional Chinese Medicine, Beijing 100700,China; 2. Department of Pharmacology,

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