中国中药杂志

2004, (08)

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肝得宁片中五味子、女贞子提取工艺研究
Studies on extraction process of Fructus Schisandrae Chinensis and Fructus Ligustri Lucidi in Gandening tablet

潘五九,肖小河,肖雪,袁海龙,赵艳玲
PAN Wu-jiu~1 , XIAO Xiao-he~1, XIAO xue~2, YUAN Hai-long~1, ZHAO Yan-ling~1(1. Department of Pharmacy,302 Hospital of People's Liberation Army,Beijing 100039,China;2. No.1 Hospital of Harbin, Harbin 150010, China )

摘要(Abstract):

目的 :为肝得宁片优化五味子、女贞子提取工艺条件。方法 :以五味子甲素转移率和得膏率为主要指标 ,结合工业化生产的可行性 ,对超临界CO2 萃取法、醇提法、水煮法等提取方法进行了比较研究 ,并采用正交设计法优选醇提工艺条件。结果 :3种提取方法以醇提法为佳 ,醇提工艺正交设计优化结果为 :乙醇浓度 90 % ,回流次数2次 ,时间为 1h ,溶媒用量为 6倍。结论 :本工艺稳定可行 ,可为提取五味子、女贞子生产工艺作参考
Objective: To optimize the combined extraction methods of Fructus Schisandrae Chinensis and Fructus Ligustri Lucidi. Method: The extraction effects of three processes (SFE CO_2, alcohol-extraction, water-extraction) were compared by the contents of deoxyschizandrin, the dried extraction yield and production feasibility. Result: The method of alcohol-extraction was the best of the three methods, and the extraction conditions were optimized by orthogonal design as follows: sixfold 90% alcohol for two times and each for one hour. Conclusion: The extraction method is steady and feasible, which can be used for reference for the extraction process of Fructus Schisandrae Chinensis and Fructus Ligustri Lucidi.

关键词(KeyWords): 肝得宁片;五味子;女贞子;正交设计;工艺优化
Gandening tablet; Fructus Schisandrae Chinensis; Fructus Ligustri Lucidi; orthogonal design ; optimization of extraction conditions

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作者(Author): 潘五九,肖小河,肖雪,袁海龙,赵艳玲
PAN Wu-jiu~1 , XIAO Xiao-he~1, XIAO xue~2, YUAN Hai-long~1, ZHAO Yan-ling~1(1. Department of Pharmacy,302 Hospital of People's Liberation Army,Beijing 100039,China;2. No.1 Hospital of Harbin, Harbin 150010, China )

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