中国中药杂志

2004, (02)

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聚乙烯醇在中药新剂型中的应用
Applications of polyvinyl alcohol in modern preparations of TCM

张韵慧,李宁,许建辰,肖莉
ZHANG Yun-hui 1, LI Ning 2, XU Jian-chen 1, XIAO Li 1 (1.College of Pharmaceuticals & Biotechnology,Tianjin University,Tianjin ,300072,China; 2.School of Materials Science and Engineering ,Tianjin University,Tianjin ,300072,China )

摘要(Abstract):

聚乙烯醇 (PVA)作为药用辅料 ,具有易溶于水、成膜性好、粘接力强、热稳定性高、毒性低、无刺激性等优点 ,近年来 ,在医药工业中应用日趋广泛。在中药现代化制剂研究中 ,PVA作为涂膜剂和膜剂的成膜材料 ,其成膜性能优良、膜的韧性好等特点 ,在涂膜剂和膜剂中有着广阔的应用前景。PVA作为巴布膏剂和凝胶剂的高分子基质 ,既能承载药物 ,又能改善制剂的使用和工艺性能 ,是一种优良的药物载体。目前 ,PVA在中药制剂中的应用 ,主要集中在外用剂型 ,随着研究的深入 ,必将拓宽PVA在中药现代化剂型中的应用范围。PVA有望在渗透泵控释制剂、载药微球、溶胀控释系统等新剂型中得到应用。
As a drug additive,polyvinyl alcohol(PVA) has merits of solubility,easy forming ,strong conglutination,high thermal stability,low toxicity and no irritation. In these years,PVA has been applied wider and wider in medicine industry. In the study of modern preparations of TCM PVA,as film material of membrane and pellicles,is very promising owing to its easy forming and excellent toughness. PVA is good polymer matrix for suppositories and gel,because it can not only carry drug but also improve the properties of preparations on application and technology. It can be said that PVA is an excellent carrier. At the present,PVA is mainly applied in vitro preparations of TCM,but its applications will be spread with further research. The prospective applications of PVA in osmotic pump controlled release preparations,drug carried microspheres and swelling controlled release system are foreseen.

关键词(KeyWords): 聚乙烯醇;药用辅料;中药;中药新剂型
polyvinyl alcohol; drug additive; TCM; TCM modern preparations

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作者(Author): 张韵慧,李宁,许建辰,肖莉
ZHANG Yun-hui 1, LI Ning 2, XU Jian-chen 1, XIAO Li 1 (1.College of Pharmaceuticals & Biotechnology,Tianjin University,Tianjin ,300072,China; 2.School of Materials Science and Engineering ,Tianjin University,Tianjin ,300072,China )

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