邵云东,高文远,刘丹,贾伟,段宏泉,张铁军
SHAO Yun-dong 1,GAO Wen-yuan 1,LIU Dan 2,JIA Wei 3,DUAN Hong-Quan 1,ZHANG Tie-jun 4 (1. The College of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China; 2.The College of Life Science and Pharmaceutical Engineering, Nanjing University of Technology, Nanjing 210009, Jiansu, China; 3. School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200030, China; 4. Tianjin Medicine Institute, Tianjin 300192, China)

• 1:天津大学药物科学与技术学院
• 2:天津大学药物科学与技术学院
• 3:南京工业大学制药与生命科学学院
• 4:上海交通大学药学院

摘要(Abstract)：

概述了植物提取物行业的国内外现状 ,并比较和分析了美国市场上畅销的前 2 0位植物提取物的产品质量控制现状。对 6个提取物品种的分析表明 ,造成植物提取物质量水平差异的主要原因有两个 ,即提取物原料使用的品种差异和不同公司提取分离的工艺差异。目前我国植物提取物的质量控制水平与国外大公司相比还不够高 ,应以色谱技术及色谱指纹图谱技术为手段 ,快速提升我国植物提取物的质量控制水平。
The current situation of plant extract in domestic and international market was analyzed in the paper. The quality control of 20 plant extracts which have reasonably good sales in USA market was compared and analyzed. The analysis of the quality control of six plant extracts indicated that there were two main reasons leading to the varied quality specifications among different suppliers. One reason was that the plant species utilized by different companies were different. The other reason was that the extraction processes were different among different production plants. Comparing with the significant international suppliers of plant extracts, the product quality of Chinese companies were not satisfactory. It was suggested that chromatography and chromatographic fingerprint techniques should be applied to improve the quality control standard of plant extract in our country.

关键词(KeyWords)： 植物提取物;质量控制;指纹图谱
plant extract; quality control; chromatography fingerprint

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 邵云东,高文远,刘丹,贾伟,段宏泉,张铁军
SHAO Yun-dong 1,GAO Wen-yuan 1,LIU Dan 2,JIA Wei 3,DUAN Hong-Quan 1,ZHANG Tie-jun 4 (1. The College of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China; 2.The College of Life Science and Pharmaceutical Engineering, Nanjing University of Technology, Nanjing 210009, Jiansu, China; 3. School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200030, China; 4. Tianjin Medicine Institute, Tianjin 300192, China)

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DOI:

参考文献(References)：

• [1]　BlumenthalM .HerbSalesDowm15PercentinMainstreamMar ket.HerbalGram,2001.51.
• [2]　ChungB .NaturalPlantExtractsExportMarketOpportunitiesintheUSA ,Chicago,USA ,PublicationNo.00/51,ISBN 0642580812.
• [3]　法制日报,2002年11月21日.
• [4]　徐长卿,王先红.加入WTO后我国茶叶卫生质量面临的问题及对策.中国标准化,2002(1):55.
• [5]　薛　建,杨世林.我国中药材农药残留污染现状及对策.中国中药杂志,2001,26(9):637.
• [6]　田金改,张曙明.两种出口中成药中有机氯农药的含量测定.中国中药杂志,2000,25(5):279.
• [7]　中国药典.一部.附录VIE .2000.40.
• [8]　美国药典.25版(USP 25).211,231,241,251.
• [9]　杨永珍.美国农药残留监控.世界农业,2001,021(10):34.
• [10]　秦路平,黄宝康.我国实行GAP的背景、现状、问题及对策.药学实践杂志,2001,19(2):67.
• [11]　陈宇照,龚跃刚.中药提取物中重金属的研究.云南中医学院学报,2001,24(1):1.
• [12]　郑虎占,董泽宏,余　靖,等.中药现代研究与应用.北京:学苑出版社,1997.10.
• [13]　石　碧,狄　莹.植物多酚.北京:科学出版社,2000.7.
• [14]　邵云东,胡光祥,於洪建,等.葡萄籽提取物质量评价.中草药,2001,32(11):1044.
• [15]　张荣庆,王红中,谢莉萍.CN1284503A
• [16]　姜浩奎.CN1315323A
• [17]　张　莹,刘　苛.紫锥菊属药用植物进展.中草药,2001,32(9):852.
• [18]　窦得明,帅　绯.引种紫锥菊菊苣酸含量研究.中草药,2001,32(11):987.
• [19]　ChandraA ,RanaJ ,LiYQ .Separation,Identification,Quan tification,andMethodValidationofAnthocyanidinsinBotanicalSupplementRawMaterialsbyHPLCandHPLC -MS .JAgricFoodChem,2001,49:3515.
• [20]　FlaminiR ,TomasiD ..TheAnthocyaninContentinBerriesoftheHybridGrapeCultivarsClintonandIsabella.Vitis,2000,39(2):79.
• [21]　邓国昌,堵年生,孙殿申,等.红景天开发研究概况.现代应用药学,1994,11(4):47.
• [22]　王　曙,游心涛,王锋鹏,等.红景天属植物中红景天苷的高效液相色谱分析.药学学报,1992,27(11):849.
• [23]　明海泉,夏光成,张瑞钧,等.红景天研究进展.中草药,1988,19(5):37.
• [24]　KiryanovAA .DeterminingBiologicallyActiveComponentsofRhodiolaRoseaRhizomes.KhimiyaPrirodnykhWoedinenii,1991,(3):320.
• [25]　SatsyperovaIF .BiologicallyActiveSubstancesinRhizomesofRhodiolaRoseaL .IintroducedinSt.Petersburg,Rastitel’nyeResursy,1993,29(2):26.