中国中药杂志

2020, v.45(12) 2765-2771

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酸枣仁汤化学成分、药理作用、临床应用的研究进展及质量标志物的预测分析
Review of chemical constituents, pharmacological effects and clinical applications of Suanzaoren Decoction and prediction and analysis of its Q-markers

王玉;杨雪;夏鹏飞;马肖;杨蕊菁;王玉霞;樊秦;赵磊;
WANG Yu;YANG Xue;XIA Peng-fei;MA Xiao;YANG Rui-jing;WANG Yu-xia;FAN Qin;ZHAO Lei;Gansu University of Chinese Medicine;Key Laboratory of Chemistry and Quality for Traditional Chinese Medicines of the College of Gansu Province, Gansu University of Chinese Medicine;Gansu Province Engineering Laboratory for Traditional Chinese Medicines Standardization Technology and Popularization;Second People′s Hospital of Gansu Province;

摘要(Abstract):

酸枣仁汤为补养心肝、益血安神的经典名方,具有镇静催眠、抗焦虑、抗抑郁、抗惊厥等作用,现代临床多用于治疗不同类型失眠、抑郁、神经衰弱、紧张性头痛及眩晕等症。该文对酸枣仁汤的化学成分、药理作用及临床应用的研究近况进行综述,基于此,根据中药质量标志物(Q-marker)"五原则"——传递与溯源、特有性、有效性、可测性及复方配伍环境对酸枣仁汤的Q-marker进行预测分析,提示酸枣仁皂苷、斯皮诺素、洋川芎内酯Ⅰ、知母皂苷元、芒果苷、甘草苷及甘草酸可作为酸枣仁汤的Q-marker,后续可选择以上成分为指标对酸枣仁汤及其制剂进行全程质量把控和评价,并建立质量溯源体系。
Suanzaoren Decoction is a classic prescription for nourishing the heart and liver, nourishing blood and tranquilizing the mind. It has the functions of sedation and hypnosis, anti-anxiety, anti-depression, anti-convulsion and so on. Modern clinic is mostly used to treat different types of insomnia, depression, neurasthenia, tension headache and vertigo. In this paper, the chemical consti-tuents, pharmacological effects and clinical application of Suanzaoren Decoction are reviewed. Based on this, the quality marker(Q-marker) of Suanzaoren Decoction was predicted and analyzed according to the "five principles" of Q-marker of traditional Chinese medicine--transmission and traceability, specificity, effectiveness, measurability and compatibility environment of compound prescriptions. The results indicated that jujuboside, spinosin, ferulic acid, senkyunolide Ⅰ, sarsasapogenin, mangiferin, liquiritoside and glycyrrhizic acid were predicted and analyzed, and those can be used as Q-markers of Suanzaoren Decoction. Subsequently, the above components can be selected as indicators to control and evaluate the quality of Suanzaoren Decoction and its preparations, and establish a quality traceability system.

关键词(KeyWords): 酸枣仁汤;质量标志物;化学成分;药理作用;临床应用;质量控制
Suanzaoren Decoction;quality marker(Q-marker);chemical constituents;pharmacological activities;clinical application;quality control

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金项目(81660577);; 甘肃省道地药材质量标准化技术研究与推广工程实验室开放基金项目(ddyc-2016-04);; 甘肃省中医药管理局科研课题(G2KLP-2014-7)

作者(Author): 王玉;杨雪;夏鹏飞;马肖;杨蕊菁;王玉霞;樊秦;赵磊;
WANG Yu;YANG Xue;XIA Peng-fei;MA Xiao;YANG Rui-jing;WANG Yu-xia;FAN Qin;ZHAO Lei;Gansu University of Chinese Medicine;Key Laboratory of Chemistry and Quality for Traditional Chinese Medicines of the College of Gansu Province, Gansu University of Chinese Medicine;Gansu Province Engineering Laboratory for Traditional Chinese Medicines Standardization Technology and Popularization;Second People′s Hospital of Gansu Province;

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