中国中药杂志

2004, (08)

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银翘挥发油/β-环糊精包合常数的测定研究
Determination of constant for the inclusion complex of Yinqiao volatile oil with β-cyclodextrin

马坤芳,任勇,王宣,冒麟
MA Kun-fang~1 , REN Yong~2 , WANG Xuan~3 , MAO Lin~3 ( 1. Center of Drug Discovery , China Pharmaceutical University, Nanjing 210009 , China; 2. Center of Drug Discovery , Nanjing Normal University, Nanjing 210097, China; 3. Hubei Minkang Pharmaceutical Company, Yichang 443002, China )

摘要(Abstract):

目的 :测定中药多组分 / β 环糊精的包合常数。 方法 :在多波长下探测银翘挥发油包合作用的紫外光谱特征 ,以经验公式处理紫外吸收 浓度关系 ,测定其包合常数 ;以相溶解度曲线验证包合比 ;以饱和水溶液法制备包合物 ,差热法进行包合物鉴定。结果 :紫外测定条件下 ,银翘挥发油 / β 环糊精包合反应能够在多波长处显示良好的线形特征 ,包合比为 1∶1。结论 :采用多波长法可测定中药多组分表观包合常数 ,该方法可作为中药包合物的定量研究方法之一
Objective: To determine the constant for the inclusion complex of Yinqiao volatile oil with β-cyclodextrin. Method: The stability constant for the inclusion complex of Yinqiao the volatile oil with β-cyclodextrin was detemined under multiwavelength by ultraviolet spectroscopy, and spectroscopy feature for inclusion complex was studied. The phase solubility-curve showed the inclusion proportion. The inclusion complex of Yinqiao the volatile oil with β-cyclodextrin was prepared by saturated aqueous solution. The DTA spectroscopy of inclusion complex was different from not only oil with β-cyclodextrin but also the mixture of them. Result: The inclusion complex of Yinqiao the volatile oil with β-cyclodextrin was formed. The experimental data of inclusion complex fitted well to the molar ratio of 1∶1. There was good liner feature under multiwavelength of ultraviolet spectroscopy. Conclusion: Adopting multiwavelength method may determine the appearant stability constant of multicomponential traditional drug. The determination of the stability constant of the inclusion complex can be used in traditional drug.[

关键词(KeyWords): 环糊精;紫外光谱法;包合常数;相溶解度曲线;差热扫描图谱
cyclodextrins; ultraviolet spectroscopy; constant of the inclusion complex; phase solubility-curve; DTA thermograms spectroscopy

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作者(Author): 马坤芳,任勇,王宣,冒麟
MA Kun-fang~1 , REN Yong~2 , WANG Xuan~3 , MAO Lin~3 ( 1. Center of Drug Discovery , China Pharmaceutical University, Nanjing 210009 , China; 2. Center of Drug Discovery , Nanjing Normal University, Nanjing 210097, China; 3. Hubei Minkang Pharmaceutical Company, Yichang 443002, China )

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