中国中药杂志

2005, (09) 662-665

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制备工艺对参麦注射液质量的影响
The effect of preparation method on the quality of Shen-mai injection

吴永江,崔勤敏,程翼宇
WU Yong-jiang, CUI Qin-min, CHENG Yi-yu(Department of Chinese Medicine Science and Engineering, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310027,China)

摘要(Abstract):

目的:考察不同制备工艺对参麦注射液质量的影响。方法:采用3种生产工艺制备参麦注射液,用HPLC测定红参药材以及不同工艺制备的红参中间体和参麦提取液的指纹图谱,并测定人参皂苷Rg1,Re总量和Rb1含量以及参麦提取液中总皂苷含量。结果:3个不同工艺的红参中间体和参麦提取液在指纹图谱和人参皂苷含量上都有显著的差异。结论:不同的提取工艺对参麦提取液质量有很大的影响,用HPLC指纹图谱法可以快速准确检测参麦提取液的质量差异。
Objective: To investigate the effect of different preparation method on the quality of Shen-mai injection. Method: The Shen-mai injection samples were prepared using three different methods. Fingerprints of Shen-mai extracts red ginseng, and its intermediates were obtained using an HPLC analytical procedure. The contents of ginsenoside Rg 1, Rc and Rb 1, and the gross saponins of Shen-mai extract were quantitatively mensured with HPLC procedures. Result: There was singificant difference in fingerprints and chemical contents of the injections prepared by the three different methods. Conclusion: The quality of Shen-mai injection was greatly influenced by the preparation method. HPLC fingerprinting method can be applied for the determination of the Shen-mai preparations.

关键词(KeyWords): 参麦注射液;中药质量;制备工艺;指纹图谱
Shen-mai injection; quality of traditional Chinese medicine; preparation method; chromatographic fingerprint

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基金项目(Foundation): 国家“十五”重大科技攻关项目(2001BA701A01);; 浙江省重大科技计划项目(021103549)

作者(Author): 吴永江,崔勤敏,程翼宇
WU Yong-jiang, CUI Qin-min, CHENG Yi-yu(Department of Chinese Medicine Science and Engineering, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310027,China)

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