中国中药杂志

2004, (12)

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金雀黄素对离体人子宫肌瘤细胞增殖的影响
Effect of genistein on human leiomyoma cell in vitro

薛晓鸥,曹爽,魏丽惠
XUE Xiao ou 1, CAO Shuang 2, WEI Li hui 1 (1 Department of Obstetrics and Gynecology,Peking University People′s Hospital, Beijing 100044, China; 2 Jinzhou Medical College, Jinzhou 121001, China)

摘要(Abstract):

目的 :观察不同浓度金雀黄素对体外培养人子宫肌瘤细胞增殖的影响。方法 :应用MTT比色法研究金雀黄素对体外培养人子宫肌瘤细胞影响的量效关系和时效关系。结果 :低浓度的金雀黄素对子宫肌瘤细胞无抑制作用 ,达到一定浓度后才表现出抑制作用 ,并且呈浓度依赖性和时间依赖性。结论 :金雀黄素对体外培养的子宫肌瘤细胞具有抑制作用 ,可为临床应用金雀黄素提供参考依据。
Objective: To observe the effect of different concentration of genistein on human uterine leiomyoma cell in vitro Method: To detect the relation of concentration effect and time effect of genistein for human uterine leiomyoma cells by MTT assay Result: Low concentration of genistein has no inhibitory effect on the human uterine leiomyoma cells The effect was only expressed when the concentration is relatively high, and it is concentration dependent and time dependent Conclusion: Genistein can inhibit the growth of human uterine leiomyoma cells in vitro, thus it may supply some suggestions with clinical therapy of uterine leiomyoma

关键词(KeyWords): 金雀黄素;人子宫肌瘤;细胞培养
gensitein; human uterine leiomyoma; cell culture

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作者(Author): 薛晓鸥,曹爽,魏丽惠
XUE Xiao ou 1, CAO Shuang 2, WEI Li hui 1 (1 Department of Obstetrics and Gynecology,Peking University People′s Hospital, Beijing 100044, China; 2 Jinzhou Medical College, Jinzhou 121001, China)

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