中国中药杂志

2019, v.44(15) 3281-3286

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黄芩饮片加工工艺标准化的初步研究
Preliminary study on standardization of production and processing of Scutellaria baicalensis pieces

胡恋琪;熊优;王雅琪;曹丽娟;杨园珍;焦姣姣;杨明;
HU Lian-qi;XIONG You;WANG Ya-qi;CAO Li-juan;YANG Yuan-zhen;JIAO Jiao-jiao;YANG Ming;Jiangxi University of Traditional Chinese Medicine;Chengdu University of Traditional Chinese Medicine;China Medico Corporation;

摘要(Abstract):

饮片作为中药制剂生产的重要原料,其质量的优劣直接影响中药的临床疗效和用药安全。中药生产加工工艺研究是实现中药饮片规范化和标准化的基础。目前黄芩饮片生产加工标准匮乏、数据基础薄弱。该研究以黄芩苷、汉黄芩苷、黄芩素、汉黄芩素的含量为指标,通过单因素实验优选黄芩软化、干燥和切制工艺,为黄芩饮片生产加工的标准化提供参考。采用相对差距和法对实验数据进行处理,综合分析不同软化方法、干燥温度和切制厚度对黄芩4种成分含量的影响。结果发现,不同软化方法和干燥温度对黄芩4种成分含量和化学成分综合指标均有显著影响,其中沸煮法的汉黄芩素含量显著高于冷煮,70℃干燥条件下苷类成分含量高于其他组;不同切制厚度对黄芩苷含量产生影响,而化学成分综合指标无显著影响。最终优化的黄芩饮片加工工艺为:黄芩药材放入沸水中煮20 min;切成薄片(1~2 mm);在70℃条件下,黄芩片平铺于烘箱中鼓风干燥烘干。工艺优选贴合实际生产、切实可行,对黄芩饮片质量的提高具有重要意义。
Decoction pieces are important raw materials in the production of traditional Chinese medicine( TCM),and their quality could directly affect the clinical efficacy and medication safety. Research on the production and processing technology of TCM is the basis for the normalization and standardization of Chinese medicine decoction pieces. At present,the production and processing standards for Scutellaria baicalensis pieces are non-regulated,lacking data foundation. In this study,with baicalin,baicalein,wogonoside and wogonin contents as evaluation indicators,single factor experiment was designed to optimize the softening,drying and cutting processes of S. baicalensis,providing a basis for the standardization of their production and processing. The effects of different softening,drying and cutting processes on the contents of the main components in S. baicalensis were comprehensively analyzed by the summation of relative differences. Results showed that the contents of the four components and comprehensive indexes were affected by different softening methods and drying temperatures. The content of wogonin in boiling method was higher than that in boiling with cold water,and the content of glycosides in 70 ℃ drying condition was higher than that in other groups. The content of baicalin was significantly affected by different cutting thicknesses,but not by comprehensive index. Eventually,the optimal preparation process for S. baicalensis was determined as follows: boiled in boiling water for 20 min,cut into thin slices( 1-2 mm),and then dried at 70 ℃ in blast drier. This process was close to the actual production,practical and feasible and meanwhile,it was of great significance to improve the quality of S. baicalensis pieces.

关键词(KeyWords): 黄芩;软化;切制;干燥;加工工艺
Scutellaria baicalensis;softening;cutting;drying;processing technology

Abstract:

Keywords:

基金项目(Foundation): 国家中药标准化项目(ZYBZH-Y-TJ-43)

作者(Author): 胡恋琪;熊优;王雅琪;曹丽娟;杨园珍;焦姣姣;杨明;
HU Lian-qi;XIONG You;WANG Ya-qi;CAO Li-juan;YANG Yuan-zhen;JIAO Jiao-jiao;YANG Ming;Jiangxi University of Traditional Chinese Medicine;Chengdu University of Traditional Chinese Medicine;China Medico Corporation;

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