中国中药杂志

2004, (08)

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如意金黄贴膏中大黄酚的释放度实验研究
Study on releasing rate of chrysophanol from Ruyi Jinhuang plaster

毛平,徐嘉,吴云鸣
MAO Ping~1, XU Jia~1, WU Yun-ming~2 (1.Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China;2. Shanghai Green Valley Holding Company Limited, Shanghai 200031, China )

摘要(Abstract):

目的 :研究如意金黄贴膏中大黄酚的释放情况。方法 :按《中国药典》(2 0 0 0年版 )透皮贴剂释放度测定法的要求和在体剩余量法 ,用HPLC色谱法对如意金黄贴膏中大黄酚进行释放度和在体敷贴后剩余量的测定。结果 :大黄酚能从贴膏中释放出来 ,并形成药物浓度梯度。结论 :如意金黄贴膏中的大黄酚有被皮肤吸收的可能
Objective: To study the releasing rate of chrysophanol from Ruyi Jinhuang plaster. Method: Based on the detecting methods of releasing rate and residual dosage applied in 《Pharmacopoeia of P.R.C》(2000 edition), the contents of chrysophanol were detected by HPLC. Result: Chrysophanol in Ruyi Jinhuang plaster could well be released from plaster and to form medicinal concentration gradient. Conclution: Chrysophanol in Ruyi-jinhuang plaster can possibly be absorbed by skin. [

关键词(KeyWords): 如意金黄贴膏;释放度;大黄酚
Ruyi Jinhuang plaster ; releasing rate; chrysophanol

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作者(Author): 毛平,徐嘉,吴云鸣
MAO Ping~1, XU Jia~1, WU Yun-ming~2 (1.Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China;2. Shanghai Green Valley Holding Company Limited, Shanghai 200031, China )

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