中国中药杂志

2001, (01)

[打印本页] [关闭]
本期目录(Current Issue) | 过刊浏览(Past Issue) | 高级检索(Advanced Search)

天麻促智颗粒对反复脑缺血再灌小鼠脑组织递质性氨基酸含量的影响
Effect of Tianma Cuzhi Keli (TMCZKL) on Contents of Transmitter Amino Acids of Brain Tissue in the Mouse Repetitious Cerebral Ischemia Reperfusion

傅建华,杜贵友
FU Jian hua *, DU Gui you (Institute of Chinese Materia Medica, China Academy of TCM, Beijing 100700,China; * Xiyuan Hospital, china Acaderny of TCM, Beijing 100092, China) [

摘要(Abstract):

目的 :为探讨天麻促智颗粒 (TMCZKL)的脑保护作用机制 ,观察了该药对反复脑缺血再灌注小鼠的脑组织递质性氨基酸含量的影响。方法 :结扎小鼠双侧颈总动脉进行反复缺血再灌注 ,造成小鼠血管性学习记忆障碍模型 ,测定小鼠大脑皮层和海马区递质性氨基酸含量的变化 ,探讨该药的脑保护作用。结果 :TMCZKL大、中、小 3个剂量组均可非常显著升高小鼠脑皮层和海马的谷氨酸含量 (P <0 .0 0 1) ,升高海马区天门冬氨酸含量 (P <0 .0 0 1) ,非常显著降低脑皮层的γ 氨基丁酸的含量 (P <0 .0 0 1)。结论 :提示TMCZKL可调节脑内递质性氨基酸含量 ,维持兴奋性氨基酸和抑制性氨基酸的动态平衡 ,从而可对抗兴奋性氨基酸毒性作用。
Objective: To research the mechanism of protective action of TMCZKL on brain, Method: Contents of transmitter amino aclds in cortex and hippocampus befort and after administration of TMCZKL were measured in mice of repetifious cerebral ischemia reperfusion. Result: The three doses of TMCZKL raised the content of glutamic acid in cortex and hippocampus the content of aspartic acid in hippocampus and decreased GABA content in cortex significantly. Conclusion: TMCZKL might antagonize ischemic injury through regulating contents of transmitter amino acids and sustain the dynamic equilibrium of EAA and IAA. [

关键词(KeyWords): 天麻促智颗粒;脑缺血;反复再灌注损伤;递质性氨基酸
Tianma Cuzhi Keli; cerebral ischemia; repetitionus reperfusion injury; transmitter amino acid

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 傅建华,杜贵友
FU Jian hua *, DU Gui you (Institute of Chinese Materia Medica, China Academy of TCM, Beijing 100700,China; * Xiyuan Hospital, china Acaderny of TCM, Beijing 100092, China) [

Email:

DOI:

扩展功能
本文信息
服务与反馈
本文关键词相关文章
本文作者相关文章
中国知网
分享