范明松,叶冠,黄成钢
FAN Ming song, YE Guan, HUANG Cheng gang (Shanghai Institute of Materia Medica, Chinese Academy of Science, Shanghai 201203, China)

• 1:中国科学院上海药物研究所
• 2:中国科学院上海药物研究所
• 3:中国科学院上海药物研究所 上海201203
• 4:上海201203

摘要(Abstract)：

目的 :研究山莴苣Lactucaindica全草的化学成分。方法 :硅胶柱色谱分离纯化 ,化学及波谱方法进行结构鉴定。结果 :分离得到 13个化合物 ,经理化及波谱数据分析鉴定为 :正二十六醇 (1) ,β 香树脂醇 (2 ) ,对羟甲基苯甲酸 (3) ,β 谷甾醇 (4) ,木犀草素 (5 ) ,齐墩果酸 (6 ) ,α 香树脂醇 (7) ,芹菜素 (8) ,胡萝卜苷 (9) ,槲皮素 (10 ) ,槲皮素 3 O 葡萄糖苷 (11) ,芹菜素 7 O 葡萄糖醛酸苷 (12 ) ,芹菜素 7 O 葡萄糖苷 (13)。结论 :其中化合物 (1) ,(3) ,(6 ) ,(12 )为首次从该植物中得到。
Objective: To study the chemical constituents from Lactuca indica. Method: The compounds were isolated with silica gel column chromatography and their structures were elucidated on the basis of chemical evidences and spectral analysis (EI MS, 1H NMR, 13 C NMR). Result: 13 compounds were identified as hexacosanol (1), β amyrin (2), p hydroxymethyl benzoic acid (3), β sitosterol (4), luteolin (5), oleanlic acid (6), α amyrin (7), apigenin (8), daucosterol (9), quercetin (10), quercetin 3 O glucoside (11), apigenin 7 O glucopyranside (12), apigenin 7 O glucoside (13). Conclusion: Compound (1), (3), (6), (12)were isolated for the first time from the title plant.

关键词(KeyWords)： 莴苣属;山莴苣;化学成分
Lactuca; Lactuca indica; chemical constituents

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 范明松,叶冠,黄成钢
FAN Ming song, YE Guan, HUANG Cheng gang (Shanghai Institute of Materia Medica, Chinese Academy of Science, Shanghai 201203, China)

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DOI:

参考文献(References)：

• [1]　王铁僧,宋国杰,郭荣麟,等.民间抗癌药用植物的整理鉴定.中成药研究,1979,(5):33.
• [2]　HuiWH ,LeeWK .TriterpenoidandsteroidconstituentsofsomeLac tucaandAgeratumspeciesofHongKong.Phytochemistry,1971,10:899.
• [3]　ChiaChungHou,ShwuJiuanLin,JueiTangCheng.AntidiabeticdimericguianolidesandalignanglycosidefromLactucaindica.JNatProd,2003,66(5):625.
• [4]　LIYun sen,WANGZheng tao,ZHANGMian.StudyontheterpenecompoundsfromLigulariakanaitaensis.JChinPharmSci,2002,11(3):115.
• [5]　任玉琳,杨峻山.西藏雪莲花化学成分研究Ⅱ.中国药学杂志,2001,36(9):590.
• [6]　于德泉,杨峻山.分析化学手册.第七分册.北京:化学工业出版社,1999.838,820.
• [7]　张　晶,郑毅男,韩立坤.旱柳叶的化学成分及其药理活性的研究.中国中药杂志,2000,25(9):538.