中国中药杂志

2020, v.45(14) 3331-3335

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激活数据学视角下的中成药精准机制研究思考
Study on precise mechanism of Chinese patent medicine from perspective of activating data

王连心;谢雁鸣;
WANG Lian-xin;XIE Yan-ming;Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences;

摘要(Abstract):

中医药辨证论治在重大疾病(无论是新发、突发传染病,还是重大慢性疾病)防治中具有疗效特色和优势,当前以西医病名、分期、分型等为适应症的临床应用,限制了中医药辨证论治作用发挥,使中医特色也难以发挥,因而中成药上市后的治疗价值和社会价值属性并不能得到切实的彰显,甚至被一概而论为辅助用药。之所以面对这样的局面,很大程度由于难以提出有别于化药的精准定位,更是鲜有精准定位的高级别、高质量循证证据,关于其作用于疾病的病理环节和疗效机制的研究同样缺乏系统性。基因组学等生物技术的发展将医学带入精准时代,为证候生物标记物的探索以及以其为参数探析疗效机制提供了思路与技术支撑。数字中国智库论坛曾提到测序技术的发展提供了人类百分之百的遗传密码,而能看懂的仅占3%,《块数据4.0:人工智能时代的激活数据学》一书提出了激活数据学的概念,可以将其看作是面向大数据的理论假说,为生物信息爆炸与临床大数据之间越发凸显的数据悖论提供了一种新的认知思维和解决方案,是架起数据跨界关联融合的桥梁。深度挖掘临床数据与组学数据的显性价值和隐性价值之后,可以使辨证论治作用的病机环节由暗知识逐渐成为明知识。因而,以中成药为先导进行中药上市后精准定位疗效机制研究,构建"以证统病-功能及病理环节-生物学内涵"精准体系,为增加品种的科技含量提供了强大的依据与支撑。
Traditional Chinese medicine(TCM) syndrome differentiation and treatment has a characteristic and advantageous efficacy in the prevention and treatment of major diseases(no matter for new or sudden infectious diseases or major chronic diseases). At present, the clinical application by Western medicine disease′s name, stage, classification and other indications limits the role of TCM syndrome differentiation and treatment, and makes TCM difficult to play its advantages. Therefore, the therapeutic value and social value attribute of Chinese patent medicine after being launched in the market cannot be effectively demonstrated, or even generalized as adjuvants. Under the circumstances, it is difficult to put forward precise positioning different from chemical drugs, with fewer high-level and high-quality evidence-based evidences for precise positioning. The research on the pathological links and therapeutic mechanism of its effect on diseases is also less systematic. The development of biotechnology, such as genomics, has brought medicine into the era of precision, providing ideas and technical support for the exploration of syndrome biomarkers and the analysis of therapeutic mechanism with them as parameters. Digital China Think Tank Forum once mentioned that the development of sequencing technology provides 100% of human genetic code, while only 3% can understand it. Block data 4.0: activation data in the era of artificial intelligence puts forward the concept of activation data, which can be regarded as a theoretical hypothesis for big data, provides a new cognitive thinking and solution for increasingly prominent data paradox between bioinformation explosion and clinical big data, and is a bridge between cross-border data association and fusion. After deeply mining the dominant and recessive value of clinical data and histological data, we can make the pathogenesis of syndrome differentiation and treatment from dark knowledge to clear knowledge. Therefore, with Chinese patent medicine as the guide, the research on the efficacy and mechanism of precise positioning of traditional Chinese medicine after marketing is carried out, and the precise system of "syndrome, disease, function, pathological link and biological connotation" is constructed, which provides a powerful basis and support for increasing the scientific and technological content of varieties.

关键词(KeyWords): 中成药;上市后评价;精准定位;效应机制;激活数据学
Chinese patent medicine;post marketing evaluation;precise positioning;effect mechanism;activation of data science

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金面上项目(81973982);; 国家重点研发计划项目(2018YFC1707400)

作者(Author): 王连心;谢雁鸣;
WANG Lian-xin;XIE Yan-ming;Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences;

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