中国中药杂志

2018, v.43(05) 891-896

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含挥发性成分中药饮片标准汤剂的制备和质量标准研究——以牡丹皮为例
Preparation and quality standard of standard decoction of Chinese herbal medicine containing volatile components-case study of Moutan Cortex

焦梦姣;邓哲;章军;王淑慧;崔文金;张国瑗;刘安;
JIAO Meng-jiao;DENG Zhe;ZHANG Jun;WANG Shu-hui;CUI Wen-jin;ZHANG Guo-yuan;LIU An;Key Laboratory of Beijing for Identification and Safety Evaluation of Chinese Medicine,Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences;Jiangxi University of Traditional Chinese Medicine;

摘要(Abstract):

制备牡丹皮饮片标准汤剂,并对其进行质量标准研究。根据中药饮片标准汤剂的制备原则,优化提取条件,制备14批牡丹皮饮片标准汤剂;采用HPLC测定指标成分丹皮酚的含量,计算其转移率,并进行汤剂出膏率、pH的测定及指纹图谱研究。14批样品的标准汤剂中丹皮酚的转移率为43.9%~67.3%,出膏率为22.0%~38.7%,pH 3.98~4.77;同时建立了牡丹皮饮片标准汤剂指纹图谱,共标定9个共有峰,计算出其相似度均大于0.9。该研究所建立的制备方法规范、重复性良好,可用于牡丹皮饮片标准汤剂的制备和质量标准研究以及为牡丹皮配方颗粒质量评价提供参考。
To prepare the standard decoction of Moutan Cortex,and research its quality standard. According to the preparation principle of standard decoction of Chinese herbal medicines,the extraction conditions were optimized,and the 14 batches of standard decoction of Moutan Cortex were prepared. The content of paeonol was determined by HPLC; the transfer rate was calculated; and the extraction rate,pH value and the fingerprint of the decoction were determined. The results showed that the transfer rate of paeonol in the standard decoction of 14 batches of samples was at the range of 43. 9%-67. 3%; the range of extraction rate was 22. 0%-38. 7%,and the pH value range was 3. 98-4. 77. At the same time,the fingerprints of 14 batches of Moutan Cortex standard decoction were established; 9 common peaks were determined,and the similarities were more than 0. 9. The preparation method in this study was standardized with good reproducibility,and can be used for the preparation and quality standard of standard decoction of Moutan Cortex,providing reference for the quality evaluation of Moutan Cortex dispensing granules.

关键词(KeyWords): 牡丹皮;标准汤剂;质量标准;指纹图谱
Moutan Cortex;standard decoction;quality standard;fingerprint

Abstract:

Keywords:

基金项目(Foundation): 国家中药标准项目(ZYBZH-Y-JY-27);; 北京市科委“十病十药”研发专项(Z171100001717029);; 中国中医科学院“十三五”重点领域研究专项(ZZ10-007)

作者(Author): 焦梦姣;邓哲;章军;王淑慧;崔文金;张国瑗;刘安;
JIAO Meng-jiao;DENG Zhe;ZHANG Jun;WANG Shu-hui;CUI Wen-jin;ZHANG Guo-yuan;LIU An;Key Laboratory of Beijing for Identification and Safety Evaluation of Chinese Medicine,Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences;Jiangxi University of Traditional Chinese Medicine;

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DOI: 10.19540/j.cnki.cjcmm.20180105.017

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