中药饮片标准汤剂研究策略Research strategies in standard decoction of medicinal slices
陈士林;刘安;李琦;杉田享;朱广伟;孙奕;代云桃;章军;张铁军;友田健久;刘昌孝;
CHEN Shi-lin;LIU An;LI Qi;Toru Sugita;ZHU Guang-wei;SUN Yi;DAI Yun-tao;ZHANG Jun;ZHANG Tie-jun;Takehisa Tomoda;LIU Chang-xiao;Institute of Chinese Materia Medica,China Academy of Chinese Medicinal Sciences;Shanghai Traditional Chinese Medicine Co.,Ltd.;TSUMURA & Co.;Research Center for New Drug Evaluation,Tianjin Institute of Pharmaceutical Research;
摘要(Abstract):
该文通过探讨国内外饮片标准汤剂相关研究状况,结合实验数据,提出中药饮片标准汤剂是以中医理论为指导、临床应用为基础,参考现代提取方法,经标准化工艺制备而成的单味中药饮片水煎剂,并规范了工艺参数和质量标准建立原则,建立标准汤剂的药效物质基准与生物学基准,提出了中药饮片标准汤剂制备及质量标准流程。中药饮片标准汤剂作为一种标准物质和标准体系,能够用于标化临床用药,规范目前临床广泛使用的包括配方颗粒在内的新型饮片形式,保障用药的准确性和剂量的一致性,解决目前饮片形式多样性带来的监管困境。中药饮片标准汤剂的研究将为配方颗粒、经典复方标准汤剂和中药药对标准汤剂的研究提供有益参考。
This paper discusses the research situation of the standard decoction of medicinal slices at home and abroad. Combined with the experimental data,the author proposes that the standard decoction of medicinal slices is made of single herb using standard process which should be guided by the theory of traditional Chinese medicine,based on clinical practice and referred to modern extraction method with a standard process. And the author also proposes the principles of establishing the specification of process parameters and quality standards and established the basis of drug efficacy material and biological reference. As a standard material and standard system,the standard decoction of medicinal slices can provide standards for clinical medication,standardize the use of the new type of medicinal slices especially for dispensing granules,which were widely used in clinical. It can ensure the accuracy of drugs and consistency of dose,and to solve current supervision difficulties. Moreover the study of standard decoction of medicinal slices will provide the research on dispensing granules,traditional Chinese medicine prescription standard decoction and couplet medicines standard decoction a useful reference.
关键词(KeyWords):
标准汤剂;中药饮片;配方颗粒
standard decoction;Chinese herbal medicines;dispensing granules
基金项目(Foundation):
作者(Authors):
陈士林;刘安;李琦;杉田享;朱广伟;孙奕;代云桃;章军;张铁军;友田健久;刘昌孝;
CHEN Shi-lin;LIU An;LI Qi;Toru Sugita;ZHU Guang-wei;SUN Yi;DAI Yun-tao;ZHANG Jun;ZHANG Tie-jun;Takehisa Tomoda;LIU Chang-xiao;Institute of Chinese Materia Medica,China Academy of Chinese Medicinal Sciences;Shanghai Traditional Chinese Medicine Co.,Ltd.;TSUMURA & Co.;Research Center for New Drug Evaluation,Tianjin Institute of Pharmaceutical Research;
参考文献(References):
- [1]董丽丽,李野,刘春波.日本汉方药发展概况及其借鉴意义[J].国际医药卫生导报,2004(13):66.
- [2]郭晓,郁洋.日本汉方药的发展及对我国中药产业的启示[J].亚太传统医药,2007(9):9.
- [3]刘芳,陈明.试论现代汤剂煎服方法的规范化[J].环球中医药,2014(5):377.
- [4]吴巧娜,谈静,何梅.银翘散标准汤剂比较研究[J].中国中医药信息杂志,2010,17(4):53.
- [5]李一宏.科学浓缩中药在台湾中医院所应用之概况[C].厦门:第二届海峡两岸(鼓浪屿)中医药发展与合作论坛暨2007海峡两岸中医药成果交流会,2007.
- [6]田军军,刘莹,冯广义.中药汤剂煎煮法和有效成分溶出率关系探讨[J].吉林中医药,2008,28(5):373.
- [7]韩培红,关晏娟.对中药汤剂煎煮器具的探讨[J/OL].中华现代中西医杂志,2005,http://journal.9med.net/html/qikan/zxyjh/zhxdzxyzz/200412212/zyzy/20080901062821910_62386.html.
- [8]丘小惠,何洁.煎煮时间及甘草配伍剂量对附子中酯型生物碱含量的影响[J].时珍国医国药,2007,18(12):3015.
- [9]张家成,章军,刘峰,等.加水量与煎煮时间对葛根芩连汤主要成分溶出量的影响[J].中国实验方剂学杂志,2013,19(1):13.
- [10]吴贵林.不同炮制和煎煮时间对大黄沉降药性的影响研究[J].中国卫生产业,2015(19):41.
- [11]梁碧彦,钟伟湘,李尚,等.附子不良反应与煎煮时间及剂量的关系[J].中国临床新医学,2015(9):864.
- [12]邵珠德,刘元涛,代龙,等.传统汤剂中煎煮时间对桂枝活性成分提取率的影响[J].辽宁中医杂志,2015(11):2169.
- [13]蓝昕,陈丽云,储秋萍.煲中药,先煎或后煎有讲究[J].自我保健,2015(11):63.
- [14]王凤霞.石膏的药性功效及临床应用文献整理研究[D].北京:北京中医药大学,2015.
- [15]张明明,谭晓梅,陈飞龙,等.葛根先煎对方剂中有效成分提取率的影响[J].中药材,2012,35(1):147.
- [16]袁联华.传统砂锅与煎药机煎煮四物汤的化学成分比较[J].中国中医药现代远程教育,2010,8(22):157.
- [17]刘凤仙.浅谈中药汤剂的制作[J].云南中医中药杂志,2008,29(2):64.
- [18]杨宏艳,付红梅.中药煎煮方法及注意事项[J].中国实用医药,2010(13):241.
- [19]杨艳环,赵瑞华.中药煎服方法研究进展[J].辽宁中医药大学学报,2011(1):30.
- [20]深圳中药饮片煎煮规范[S].SZDB/Z 47-2011.
- [21]上海中药行业零售药店中药煎药服务管理规范[S].沪中药协字(2015)第002号.
- [22]陈士林.中国药典中药材DNA条形码标准序列[M].北京:科学出版社,2015.
- [23]郑虎占,魏宝忠,刘迪谦.《伤寒论》与《金匮要略》汤剂煎煮方法初探[C].北京:2011年全国中药调剂与临床合理用药学术会议,2011.
- [24]王力智,刘冰.中药煎剂药量、加水量、火候、煎煮时间和煎取量间关系的实验探讨[J].中国药房,1997(2):94.
- [25]李学林,孟菲.浅析影响汤剂煎煮质量的因素[J].中医杂志,2006,47(6):421.
- 陈士林
- 刘安
- 李琦
- 杉田享
- 朱广伟
- 孙奕
- 代云桃
- 章军
- 张铁军
- 友田健久
- 刘昌孝
CHEN Shi-lin- LIU An
- LI Qi
- Toru Sugita
- ZHU Guang-wei
- SUN Yi
- DAI Yun-tao
- ZHANG Jun
- ZHANG Tie-jun
- Takehisa Tomoda
- LIU Chang-xiao
- Institute of Chinese Materia Medica
- China Academy of Chinese Medicinal Sciences
- Shanghai Traditional Chinese Medicine Co.
- Ltd.
- TSUMURA & Co.
- Research Center for New Drug Evaluation
- Tianjin Institute of Pharmaceutical Research
- 陈士林
- 刘安
- 李琦
- 杉田享
- 朱广伟
- 孙奕
- 代云桃
- 章军
- 张铁军
- 友田健久
- 刘昌孝
CHEN Shi-lin- LIU An
- LI Qi
- Toru Sugita
- ZHU Guang-wei
- SUN Yi
- DAI Yun-tao
- ZHANG Jun
- ZHANG Tie-jun
- Takehisa Tomoda
- LIU Chang-xiao
- Institute of Chinese Materia Medica
- China Academy of Chinese Medicinal Sciences
- Shanghai Traditional Chinese Medicine Co.
- Ltd.
- TSUMURA & Co.
- Research Center for New Drug Evaluation
- Tianjin Institute of Pharmaceutical Research