中国中药杂志

2015, v.40(03) 373-381

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黄酮类化合物抗肿瘤活性及机制研究进展
Advance in studies on anti-cancer activity and mechanism of flavonoids

杨楠;贾晓斌;张振海;孙娥;严红梅;
YANG Nan;JIA Xiao-bin;ZHANG Zhen-hai;SUN E;YAN Hong-mei;Key Laboratory of New Drug Delivery System of Chinese Materia Medica,Jiangsu Provincial Academy of Chinese Medicine;Nanjing University of Chinese Medicine;

摘要(Abstract):

黄酮类化合物是一类天然产物,在自然界中普遍存在,具有生理活性广泛,毒副作用低的特点。近年来,其抗肿瘤作用得到了广泛的关注和研究。研究结果表明,黄酮类化合物对多种常见癌症如肺癌、乳腺癌、结肠癌、前列腺癌、肝癌、白血病、卵巢癌、胃癌等皆有显著的防治效果。黄酮类化合物抗肿瘤的机制主要有:抗氧化抗自由基、诱导肿瘤细胞凋亡、影响细胞周期,调节免疫、抑制肿瘤新生血管、抑制环氧合酶2、抑制端粒酶活性等。该文综述了近年来国内外对黄酮化合物抗肿瘤活性及其机制的研究进展,以期为黄酮类化合物的进一步开发和临床应用提供理论基础和研究思路。
Flavonoids are natural products that are ubiquitous in the natural world,with wide physiological activities and low toxic and side effects. In recent years,their anti-tumor effect has caused widespread concern and studies. According to the findings,flavonoids have prominent effects in preventing and treating lung cancer,breast cancer,colon cancer,prostate cancer,liver cancer,leukemia,ovarian cancer,gastric cancer and so on. Their anti-tumor mechanisms mainly include anti-oxidation,anti-free radical,induction of apoptosis of cancer cells,impact on cell cycle,immune regulation,inhibition of tumor angiogenesis,inhibition of COX-2,inhibition of telomerase activity and so on. This article focuses on the advance in domestic and foreign studies on anti-cancer activity and mechanism of flavonoids,in order to provide theoretical basis and research ideas for the further development and clinical application of flavonoids.

关键词(KeyWords): 黄酮;抗肿瘤;机制
flavonoids;anti-tumor;mechanism

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基金项目(Foundation): 国家自然科学基金项目(81274088)

作者(Author): 杨楠;贾晓斌;张振海;孙娥;严红梅;
YANG Nan;JIA Xiao-bin;ZHANG Zhen-hai;SUN E;YAN Hong-mei;Key Laboratory of New Drug Delivery System of Chinese Materia Medica,Jiangsu Provincial Academy of Chinese Medicine;Nanjing University of Chinese Medicine;

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