中国中药杂志

2004, (10)

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丹参注射液及其活性成分丹参素、原儿茶醛对人红细胞胞浆Ca~(2+)浓度影响的实验研究
Effect of danshensu, protocatechualdehyde and Danshen injection on calciumion concentration in cytoplasm of human erythrocytes

沈玲红,王彬尧,王长谦,谢秀兰,俞国瑞,姚中一,朱元龙,杨葆津
SHEN Ling-hong 1, WANG Bin-yao 1, WANG Chang-qian 1, XIE Xiu -lan 1, YU Guo-rui 2, YAO Zhong-yi 2, ZHU Yuan-long 2, YANG Bao-jin 2 (1. Department of Cadiology, Renji Hospital of Shanghai Second Medi cal University, Shanghai 200001, China; 2. Shanghai Ben-cao Bio-medicine Institute, Shanghai 200040, China) [

摘要(Abstract):

目的 :探讨丹参水溶性部位钙拮抗作用的主要有效成分。方法 :采用荧光探针Fura 2定量分析法 ,分别测定丹参注射液及其活性成分丹参素、原儿茶醛对离体健康成人红细胞胞浆Ca2 + 浓度的影响。结果 :丹参素和原儿茶醛均有降低成人红细胞胞浆Ca2 + 浓度的作用 ,并表现出剂量依赖性 ,二者合并用药 ,药效相加 ,作用与丹参注射液相似。结论 :丹参素和原儿茶醛可能是丹参注射液钙拮抗作用的主要有效成分。
Objective: To study the predominant calcium-an ta gonist components of Danshen injection. Method:The effects of danshensu, protocatechualdehyde and Danshen injection on calcium concentratio n in cytoplasm of erythrocytes were examined in vitro by the fluorescent Ca 2+ -chelator fura-2. Result: Either DS182 or PCAD can d ecrease in dose-dependent cytosolic free calcium concentration in human erythro cytes. They had additive effect when mixed, which was similar to Danshen inje ction. Conclusion: DS182 and PCAD may be predominant calcium- antagonist components of Danshen injection. [

关键词(KeyWords): 丹参注射液;丹参素;原儿茶醛;钙离子;红细胞
Danshen injection; danshensu; protocatechuald ehyde; Ca 2+ ; erythrocyte

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作者(Author): 沈玲红,王彬尧,王长谦,谢秀兰,俞国瑞,姚中一,朱元龙,杨葆津
SHEN Ling-hong 1, WANG Bin-yao 1, WANG Chang-qian 1, XIE Xiu -lan 1, YU Guo-rui 2, YAO Zhong-yi 2, ZHU Yuan-long 2, YANG Bao-jin 2 (1. Department of Cadiology, Renji Hospital of Shanghai Second Medi cal University, Shanghai 200001, China; 2. Shanghai Ben-cao Bio-medicine Institute, Shanghai 200040, China) [

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