中国中药杂志

2011, v.36(22) 3134-3136

[打印本页] [关闭]
本期目录(Current Issue) | 过刊浏览(Past Issue) | 高级检索(Advanced Search)

传统中药交让木Daphniphyllum macropodum生物碱成分的分离鉴别
Chemical studies on alkaloids of Chinese medicinal herbs Daphniphyllum macropodum

贺秀丽;王松华;赵延国;
HE Xiuli,WANG Songhua,ZHAO Yanguo(Afilliated Hospital of Shandong Academy of Medical Sciences,Ji′nan 250031,China)

摘要(Abstract):

目的:对采自中国广西的传统中药交让木Daphniphyllum macropodum的生物碱成分进行研究,从中寻找有生物活性的次生代谢产物。方法:用硅胶柱色谱和凝胶柱色谱对交让木D.macropodum氯仿提取物进行分离纯化;根据其理化性质,结合现代波谱技术(MS,NMR等)并与文献报道的数据相比较,对得到的化合物进行结构鉴定。结果:分离得到了4个具有不同骨架的虎皮南生物碱,其结构分别鉴定为:longistylumphylline A(1),deoxycalyciphylline B(2),daphnicyclidin B(3),daphnicyclidin H(4)。结论:4个化合物均系首次从该种植物中分离得到;daphnicyclidin H(4)的发现,进一步证明了它与之前报导的macropodumines A~C在生源上的密切联系。
Objective: To study the alkaloids of the Chinese medicinal herbs Daphniphyllum macropodum for in search for new bioactive substances.Method: The CHCl3 extract of D.macropodum was subjected to repeated column chromatography on silica gel to afford four pure compounds(1-4).Their structures were determined on the basis of detailed spectroscopic analysis and comparison with the data reported in the literature.Result: The four known compounds were isolated and elucidated as Daphniphyllum alkaloids with different carbon skeletons,namely longistylumphylline A(1),deoxycalyciphylline B(2),daphnicyclidin B(3) and H(4),respectively.Conclusion: All compounds were isolated from the titled plant for the first time.The discovery of daphnicyclidin B(3) and H(4) further confirmed the biogenetic relationship between the two compounds and the previously reported macropodumines A-C,found in the same plant.

关键词(KeyWords): 交让木Daphniphyllum macropodum;虎皮楠生物碱;分离纯化;结构鉴定
Daphniphyllum macropodum;Daphniphyllum alkaloids;isolation;structural elucidation

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 贺秀丽;王松华;赵延国;
HE Xiuli,WANG Songhua,ZHAO Yanguo(Afilliated Hospital of Shandong Academy of Medical Sciences,Ji′nan 250031,China)

Email:

DOI:

扩展功能
本文信息
服务与反馈
本文关键词相关文章
本文作者相关文章
中国知网
分享