中国中药杂志

2010, v.35(06) 768-771

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益气养阴消癥通络中药对早期糖尿病大鼠肾组织p38 MAPK信号通路的影响
Effect of supplementing Qi-nourishing Yin-dispersing blood stasis-dredging collateral herbs on p38 MAPK signaling pathway in kidney of early diabetic rats

赵雯红;陈志强;张江华;孙玉凤;王月华;王会青;
ZHAO Wenhong1,CHEN Zhiqiang1*,ZHANG Jianghua2,SUN Yufeng3,WANG Yuehua1,WANG Huiqing3(1.Urology Department,Hospital of Chinese Medicine of Hebei Medical University,Shijiazhuang 050011,China;2.Research Stations of Chinese Combined with Western Medicine,Hebei Medical University,Shijiazhuang 050017,China;3.Digestive System Department,The Second hospital of Hebei Medical University,Shijiazhuang 050000,China)

摘要(Abstract):

目的:探讨益气养阴消癥通络中药对早期糖尿病大鼠肾组织p38MAPK信号通路的作用。方法:将SD大鼠随机分为6组:单纯肾切组、模型组、厄贝沙坦组、中药低、中、高剂量组,按各组相应药物剂量灌胃。于第6周末检测各组大鼠24 h尿蛋白(UPro)量及肾功能水平;肾皮质p38MAPK mRNA,p-p38MAPK蛋白表达水平。结果:厄贝沙坦、中药低、中剂量组与模型组比较Upro量显著下降(P<0.05);治疗组与模型组比较,肾功能明显改善(P<0.05),且p38MAPK mRNA,p-p38MAPK蛋白表达水平显著下降(P<0.05)。结论:益气养阴消癥通络中药可能通过抑制p38MAPK信号通路表达,发挥对糖尿病肾病大鼠的治疗作用。
Objective: To study the effect of supplementing Qi-nourishing Yin and dispersing blood stasis-dredging collateral herbs on p38 mitogen activated protein kinase(p38 MAPK) signaling pathway in the kidney of early diabetic rats.Method: Dividing SD rats randomly into 6 groups: Simple nephrectomy group,model group,irbesatan group,traditional Chinese medicine(TCM) low dose group,TCM middle dose group and TCM high dose group.Each group of rats was fed with the corresponding dose of medicine.After 6 weeks,detecting 24 h urine protein(UPro) level,renal function,p38 MAPK mRNA and p-p38MAPK protein level.Result: UPro levels of irbesatan group,TCM low group and TCM middle dose group decreased significantly(P<0.05),compared with that of the model group.Renal function of the treated groups was improved greatly and their p38 MAPK mRNA and p-p38MAPK protein levels decreased significantly(P<0.05),compared with those of the model group.Conclusion: Supplementing Qi-nourishing Yin-dispersing blood stasis-dredging collateral herbs could treat DN rats effectively by inhibiting the expression of p38 MAPK signaling pathway.

关键词(KeyWords): 益气养阴消癥通络中药;糖尿病肾病大鼠;p38MAPK信号通路
supplementing Qi-nourishing Yin-dispersing blood stasis-dredging collateral herbs;DN rats;p38MAPK signaling pathway

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基金项目(Foundation): 河北省卫生厅项目(08165)

作者(Authors): 赵雯红;陈志强;张江华;孙玉凤;王月华;王会青;
ZHAO Wenhong1,CHEN Zhiqiang1*,ZHANG Jianghua2,SUN Yufeng3,WANG Yuehua1,WANG Huiqing3(1.Urology Department,Hospital of Chinese Medicine of Hebei Medical University,Shijiazhuang 050011,China;2.Research Stations of Chinese Combined with Western Medicine,Hebei Medical University,Shijiazhuang 050017,China;3.Digestive System Department,The Second hospital of Hebei Medical University,Shijiazhuang 050000,China)

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