中国中药杂志

2004, (02)

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苦参碱类抗肿瘤作用机制研究的新进展
Recent research progress of anti-tumor mechnism matrine

张鸣杰,黄建
ZHANG Ming-jie,HUANG Jian (The Second Affiliative Hospital of Zhejiang University,Hangzhou 310009, China)

摘要(Abstract):

苦参碱类生物碱作为一种传统中药的活性成分 ,在抗炎、抗心律失常、抗肝纤维化等方面有重要的应用价值 ,笔者就目前对苦参碱类在抑制肿瘤增殖、诱导分化和凋亡、抗肿瘤浸润和远处转移、抑制肿瘤新生血管形成、减轻致肿瘤炎症和抑制肿瘤耐药性、减低化疗不良作用、增强肿瘤宿主免疫功能 ,肿瘤预防性化疗等各个方面的作用及其机制的最新研究进展作一综述。
Matrine,as an active component of Chinese traditional medicine,has a great effect on anti-inflammation,anti-arrhythmia and anti-fibrosis of liver cell. But the recent evidences indicate that matrine also plays an important role in anti-tumor,such as inhibiting proliferation,inducing differation and apoptosis,reducing invasion and metastasis of tumor cell,In the review we summarized the recent research progress of anti-tumor mechanism of matrine.

关键词(KeyWords): 苦参碱;肿瘤;中药
matrine; tumor; Chinese medicine

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基金项目(Foundation): 浙江省自然科学基金资助项目 (8C0 10 5 5 )

作者(Author): 张鸣杰,黄建
ZHANG Ming-jie,HUANG Jian (The Second Affiliative Hospital of Zhejiang University,Hangzhou 310009, China)

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