中国中药杂志

2015, v.40(23) 4672-4679

[打印本页] [关闭]
本期目录(Current Issue) | 过刊浏览(Past Issue) | 高级检索(Advanced Search)

海藻玉壶汤加减甘草-海藻反药药对不同组方中11种活性成分在正常大鼠体内的药动学比较研究
Comparisons of pharmacokinetic profile of eleven bioactive components in Haizao Yuhu decoction modified with Haizao and Gancao anti-drug pair in normal rats

张洋;钱大玮;潘瑛;翟燕娟;周学平;钟赣生;朱振华;段金廒;
ZHANG Yang;QIAN Da-wei;PAN Ying;ZHAI Yan-juan;ZHOU Xue-ping;ZHONG Gan-sheng;ZHU Zhen-hua;DUAN Jin-ao;Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization,and National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine,Nanjing University of Chinese Medicine;The No.1 Clinical Medical College,Nanjing University of Chinese Medicine;Basic Medical College,Beijing University of Chinese Medicine

摘要(Abstract):

海藻玉壶汤是含有甘草-海藻反药药对的古代名方之一,用于治疗各种甲状腺疾病,其临床应用较为广泛。该文采用UPLC-TQ-MS对大鼠灌胃给药不同组方海藻玉壶汤中血中11种生物活性成分进行测定,同时比较不同组方之间11种活性成分药动学差异,探讨了海藻玉壶汤与甘草-海藻反药药对的相互影响。首次建立了甘草苷、柚皮苷、橙皮苷、贝母素甲、贝母素乙、甘草酸、甘草素、佛手柑内酯、川陈皮素、蛇床子素与甘草次酸同时测定的UPLC-MS/MS含量测定方法。结果发现,海藻可提高甘草酸的峰浓度,海藻玉壶汤中其他组分可能促进甘草中黄酮类成分在正常大鼠体内的吸收,却抑制了皂苷类成分的吸收,加快甘草中某些皂苷类成分的代谢;甘草与海藻反药药对可提高橙皮苷、佛手柑内酯、川陈皮素、蛇床子素与贝母素甲的生物利用度,减慢柚皮苷与贝母素甲的消除。
Haizao Yuhu decoction( HYD) is a formula that has been used for approximately 500 years and famous for its efficiency in treating thyroid-related diseases in traditional Chinese medicine( TCM). HYD was first presented by Chen Shi-gong in a famous surgical monograph named Waike Zhengzong during the Ming Dynasty. We conducted the research to investigate the possible pharmacokinetic profile of different prescriptions of HYD in rats,in order to reveal the interactions of Haizao and Gancao drug pair with other herbs in HYD. Liquiritin,naringin,hesperidin,peimine,peiminine liquiritigenin,glycyrrhizic acid,bergapten,nobiletin,osthole,glycyrrhetinic acid in blood samples were determined by UPLC-MS / MS. The result revealed that Haizao could enhance the peak concentration of glycyrrhizic acid. The other herbs in HYD may promote the absorption of flavonoids in Gancao in normal rats,but inhibit the absorption of saponins and accelerate their metabolism. Gancao and Haizao drug pair could enhance the bioavailability of hesperidin,peimine,bergapten,nobiletin and osthole and prolong the elimination of peimine and naringin.

关键词(KeyWords): 海藻玉壶汤;甘草-海藻反药药对;UPLC-MS/MS;多成分;药动学影响
Haizao Yuhu decoction;Haizao and Gancao anti-drug pair;UPLC-MS/MS;multiple components;pharmacokinetic effects

Abstract:

Keywords:

基金项目(Foundation): 国家重点基础研究发展计划(973)项目(2011CB505300,2011CB505306)

作者(Author): 张洋;钱大玮;潘瑛;翟燕娟;周学平;钟赣生;朱振华;段金廒;
ZHANG Yang;QIAN Da-wei;PAN Ying;ZHAI Yan-juan;ZHOU Xue-ping;ZHONG Gan-sheng;ZHU Zhen-hua;DUAN Jin-ao;Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization,and National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine,Nanjing University of Chinese Medicine;The No.1 Clinical Medical College,Nanjing University of Chinese Medicine;Basic Medical College,Beijing University of Chinese Medicine

Email:

DOI:

参考文献(References):

扩展功能
本文信息
服务与反馈
本文关键词相关文章
本文作者相关文章
中国知网
分享