中国中药杂志

2018, v.43(05) 861-867

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大黄标准汤剂质量评价
Quality evaluation of Rhei Radix et Rhizoma decoction

赵曼佳;赵嵘;代云桃;陈士林;李琦;范自全;王丹丹;友田健久;
ZHAO Man-jia;CHAO Jung;DAI Yun-tao;CHEN Shi-lin;LI Qi;FAN Zi-quan;WANG Dan-dan;Takehisa Tomoda;School of Chinese Materia Medica,Beijing University of Chinese Medicine;Institute of Chinese Materia Medica,China Academy of Chinese Medicinal Sciences;Shanghai Traditional Chinese Medicine Co.,Ltd.;Waters Corporation(Shanghai);Tsumura & Co.;

摘要(Abstract):

中药饮片标准汤剂是标化中药不同用药形式的参照物,为解决中药配方颗粒等不同中药现代剂型存在的质量不均一、质量标准不明确等问题提供了新的方向。该文将建立大黄标准汤剂的质量评价方法,为临床汤剂和配方颗粒等常用剂型的质量控制提供参考。收集有代表性的10批合格的大黄药材,建立大黄汤剂指纹图谱,采用UPLC-Q-TOF-MS对主要色谱峰进行结构确认,明确汤剂中主要成分为蒽醌类;标准汤剂出膏率为(28.1±3.8)%、转移率为(19.9±6.3)%。该文建立了大黄标准汤剂的质量评价方法,为所有源于大黄汤剂的终端产品的质量控制方法的制定提供参考。
Decoction of single medicinal herb is a reference for the standardization of different dosage forms of Chinese medicine and it provides a new direction for solving the problems existing in the quality of Chinese medicinal granules such as no uniform dosage form and no clear quality standard. In this paper,the quality evaluation method of standard decoction of rhubarb was established to provide reference for the quality control of common dosage forms such as clinical decoction and formula granule. 10 batches of representative Rhei Radix et Rhizoma were collected to establish UPLC fingerprints were established. The chemical structures of main peaks were identified with ultra-performance liquid chromatography with quadrupole-time-of-flight mass spectrometry(UPLC-Q-TOF-MS) and the main components in the decoction were Anthraquinones. The extraction ratio of the standard decoction was(28. 1 ± 3. 8) % and the transfer rate was(19. 9 ± 6. 3) %. The method for the quality evaluation of standard decoction of Rhei Radix et Rhizoma was established in this study,providing reference for the quality control method of terminal products from decoction of Rhei Radix et Rhizoma.

关键词(KeyWords): 标准汤剂;大黄;质量评价;指纹图谱;质谱鉴定;出膏率;转移率
decoction of single medicinal herb;Rhei Radix et Rhizoma;quality evaluation;fingerprint;mass spectrometry;extraction ratio;transfer rate

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金面上项目(81473340)

作者(Author): 赵曼佳;赵嵘;代云桃;陈士林;李琦;范自全;王丹丹;友田健久;
ZHAO Man-jia;CHAO Jung;DAI Yun-tao;CHEN Shi-lin;LI Qi;FAN Zi-quan;WANG Dan-dan;Takehisa Tomoda;School of Chinese Materia Medica,Beijing University of Chinese Medicine;Institute of Chinese Materia Medica,China Academy of Chinese Medicinal Sciences;Shanghai Traditional Chinese Medicine Co.,Ltd.;Waters Corporation(Shanghai);Tsumura & Co.;

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DOI: 10.19540/j.cnki.cjcmm.20180117.009

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