中国中药杂志

2004, (01)

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含马兜铃酸中药的肾脏毒性研究概况
Studies on the renal toxicity caused by aristolochic acids (AAs) and Chinese herbs containing AAs

梁爱华,丁晓霜,刘保延
LIANG Ai-hua, DING Xiao-shuang, LIU Bao-yan (Institute of Chinese Materia Medica, China Academy of Traditional Chinese Med icine, Beijing, 100700, China)

摘要(Abstract):

近年来马兜铃酸和含马兜铃酸中药的肾脏毒性研究结果表明 ,马兜铃酸和含马兜铃酸中药引起的肾脏毒性部位主要是肾小管 ,肾小球病变不明显。大剂量短期用药引起的病变以急性肾小管上皮细胞变性和坏死为主 ,而长期用药可能引起慢性肾间质纤维化并呈进行性发展。其引起的急、慢性肾损害严重时可发生肾功能衰竭。临床上应用这类中药时应密切监测肾脏功能 ,注意用药剂量和用药时间 ,防止肾毒性的发生
The article summarized the general situation of the study on the renal toxicity caused by aristolochic acids (AAs) and Chinese herbs containing AAs. The renal l esion induced by AAs and Chinese herbs containing AAs locates mainly in renal tu b ules, and glomeruluses have no obvious histological change. The short term admin istration of large doses causes acute renal epithelia denaturalization and tubul ar necrosis, but the long-term administration may result in chronically progres s ive interstitial fibrosis of the kidney. Renal failure may occur following both acute and chronic renal lesion. The renal function should be strictly monitored while one is using the Chinese herbs containing AAs, and the dosage and duration for the treatment must be limited to prevent renal toxicity.

关键词(KeyWords): 马兜铃酸;含马兜铃酸中药;肾间质纤维化;肾脏毒性
aristolochic acids; Chinese herbs containi ng aristolochic acids; renal interstitial fibrosis; renal toxicity

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基金项目(Foundation): 国家中医药管理局重大项目 (国中医药科2 0 0 1ZDZX0 4 )

作者(Author): 梁爱华,丁晓霜,刘保延
LIANG Ai-hua, DING Xiao-shuang, LIU Bao-yan (Institute of Chinese Materia Medica, China Academy of Traditional Chinese Med icine, Beijing, 100700, China)

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