中国中药杂志

2018, v.43(01) 100-108

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蜘蛛香乙酸乙酯部位化学成分的研究
Chemical constituents from ethyl acetate-soluble extraction of Valeriana jatamansi

林生;付芃;沈云亨;叶霁;张中晓;杨献文;李慧梁;柳润辉;徐希科;张卫东;
LIN Sheng;FU Peng;SHEN Yun-heng;YE Ji;ZHANG Zhong-xiao;YANG Xian-wen;LI Hui-liang;LIU Run-hui;XU Xi-ke;ZHANG Wei-dong;College of Pharmacy,Second Military Medical University;State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College;

摘要(Abstract):

运用正相和反相硅胶柱色谱、凝胶柱色谱、大孔吸附树脂柱色谱、反相高效液相色谱等分离和纯化方法,从蜘蛛香乙酸乙酯部位中共分离得到173个化合物。应用一维和二维NMR,UV,IR,MS等波谱方法鉴定了它们的结构,化合物类型涉及环烯醚萜、倍半萜、单萜、三萜、木脂素、黄酮、简单芳香类等,其中新化合物77个。前期已对68个新化合物和25个已知化合物进行了报道。该文报道余下9个新化合物(1~9)和71个已知化合物的分离和结构鉴定,valeriotriate A(8a)的结构修正,以及肿瘤细胞毒活性筛选。
Application of a combination of various chromatographic techniques including column chromatography over silica gel,Sephadex LH-20,macroporous adsorbent resin,and reversed-phase HPLC,led to the isolation of 173 compounds including irdidoids,monoterpenes,sesquiterpenes,triterpenes,lignans,flavonoids,and simple aromatic derivatives from the ethyl acetate-soluble fraction of the whole plants of Valeriana jatamansi(Valerianaceae),and their structures were elucidated by spectroscopic methods including 1D,2D NMR UV,IR,and MS techniques.Among them,77 compounds were new.In previous reports,we have described the isolation,structure elucidation,and bioactivities of 68 new and 25 known compounds.As a consequence,we herein reported the isolation and structure elucidation of the remaining 9 new and 71 known compounds,the structure revision of valeriotriate A(8a),as well as cytotoxicity of some compounds.

关键词(KeyWords): 败酱科;蜘蛛香;化学成分;细胞毒
Valerianaceae;Valeriana jatamansi;chemical constituents;cytotoxicity

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金项目(81522050,81230090,81520108030,21472238);; 上海科学基金项目(12401900801,13401900103,13401900101)

作者(Author): 林生;付芃;沈云亨;叶霁;张中晓;杨献文;李慧梁;柳润辉;徐希科;张卫东;
LIN Sheng;FU Peng;SHEN Yun-heng;YE Ji;ZHANG Zhong-xiao;YANG Xian-wen;LI Hui-liang;LIU Run-hui;XU Xi-ke;ZHANG Wei-dong;College of Pharmacy,Second Military Medical University;State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College;

Email:

DOI: 10.19540/j.cnki.cjcmm.20171027.008

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