中国中药杂志

1996, (02) 53-54+65

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甲基莲心碱对血管平滑肌α受体引起~(45)Ca外溢与内流的影响
Effects of Neferine on the 45 Ca influx and Efflux Induced by Activation of α 1 Adrenoceptor of Vascular Smooth Muscle

王永信
Wang Yongxin (Xuzhou Municipal Institute of Medical Sciences Jiangsu 221006)

摘要(Abstract):

在血管平滑肌,甲基莲心碱能明显减少苯肾上腺素引起的45Ca内流量,不影响高钾引起的45Ca内流;而硝苯吡啶几乎完全阻断后一种的45Ca内流。甲基莲心碱不抑制45Ca外溢。
Experiments have shown that in the vascular smooth muscle neferine(Nef) can markedly reduce the 45 Ca influx induced by phenylephrine,but does not affect the 45 Ca influx induced by 100 mmol/L KCl, which is almost completely inhibited by nifedipine.Neferine does not inhibit 45 Ca efflux.

关键词(KeyWords): 甲基莲心碱,血管平滑肌,~(45)Ca内流,~(45)Ca外溢,Ca~(2+)通道阻断
neferine;vascular smooth muscle; 45 Ca influx; 45 Ca efflux;Ca 2+ channel blockade (original article on page 117)

Abstract:

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基金项目(Foundation):

作者(Author): 王永信
Wang Yongxin (Xuzhou Municipal Institute of Medical Sciences Jiangsu 221006)

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