中国中药杂志

2010, v.35(03) 378-380

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脂/水分配预测10-羟基喜树碱在大鼠小肠中的吸收
Prediction of absorption of 10-hydroxycamptothecin in small intestines of rats with its partition coefficients in phases of liposomes and water

索绪斌;李慕玲;王玉强;朱盛山;
SUO Xubin1,2,LI Muling2,WANG Yuqiang2,ZHU Shengshan1 (1.Research and Development Institute of Traditional Chinese Materia Medica,Guangdong Pharmaceutical University,Guangzhou 510006,China; 2. School of Pharmacy,Jinan University,Guangzhou 510632,China)

摘要(Abstract):

目的:探讨脂质体/水(脂/水)相中的分配,预测10-羟基喜树碱(HCPT)在大鼠小肠中吸收的可行性。方法:采取在体小肠吸收模型,研究不同pH条件下HCPT在大鼠小肠中的吸收;采取平衡透析法检测不同pH条件下药物在脂质体/水相中分配系数;探讨HCPT在脂质体/水相中分配与药物的在体吸收的相关性。结果:HCPT在脂质体/水相中的分配及在体小肠吸收随外界环境pH的不同而改变,两者相关性良好。结论:用脂质体/水相中的分配可以预测HCPT在大鼠小肠中的吸收。
This paper explore the possibility of using the partition of 10-hydroxycamptothecin in the phases of liposome and water to predict the absorption of the drug in small intestine of rats. In order to certify this theory,the in vivo absorption model have been used to study the absorption of 10-hydroxycamptothecin in the small intestine of rats while altering the pH of the medium. The correlation has been explored between the partition of drug in the phases of liposome and water and the absorption of drug in the small intestines of rats. And it was found that the partition of 10-hydroxycamptothecin in the phases of liposome and water and the absorption of the drug in small intestines of rats altered with the changes of pH,and there existed a good relative coefficient between them. All of these indicated that partition of 10-hydroxycamptothecin in phases of liposome and water can be used to predict its absorption in small intestines of rats.

关键词(KeyWords): 10-羟基喜树碱;脂质体/水相;小肠吸收
10-hydroxycamptothecin; phases of liposome/water; absorption in small intestines

Abstract:

Keywords:

基金项目(Foundation): 广东药学院“重点培养青年教师”基金项目(200809052)

作者(Authors): 索绪斌;李慕玲;王玉强;朱盛山;
SUO Xubin1,2,LI Muling2,WANG Yuqiang2,ZHU Shengshan1 (1.Research and Development Institute of Traditional Chinese Materia Medica,Guangdong Pharmaceutical University,Guangzhou 510006,China; 2. School of Pharmacy,Jinan University,Guangzhou 510632,China)

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