中国中药杂志

2011, v.36(04) 462-464

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中国红参化学成分的研究
Chemical constituents of Chinese red ginseng

刘丹;濮社班;钱士辉;张静岩;
LIU Dan1,2,PU Sheban1*,QIAN Shihui2*,ZHANG Jingyan1,2(1.China Pharmaceutical University,Nanjing 211198,China; 2.Jiangsu Institute of Traditional Chinese Medicine,Nanjing 210028,China)

摘要(Abstract):

目的:研究五加科人参属常用中药红参的化学成分。方法:采用硅胶柱色谱、反相柱色谱、Sephadex LH-20柱色谱、半制备液相色谱等方法分离纯化,根据理化性质和波谱鉴定化合物的结构。结果:从红参中分离并鉴定了14个化合物,结构分别为:三七皂苷R2(1),20(S)-人参皂苷Rg3(2),20(R)-人参皂苷Rg3(3),20(S)-人参皂苷Rg2(4),20(R)-人参皂苷Rg2(5),20(S)-人参皂苷Rh1(6),20(R)-人参皂苷Rh1(7),人参皂苷Rh4(8),-Ro(9),-Rb1(10),-Rg1(11),-Re(12),-Rf(13),麦芽酚(14)。结论:化合物1,4,6为首次从红参中分到的人参皂苷类成分。化合物2与3,4与5,6与7分别为3对对映异构体,其中对映异构体6与7为首次分离得到的单体。
The chemical constituents of Chinese red ginseng(Panax ginseng) were investigated.The chemical constituents were isolated and purified by silca gel,ODS,and Sephedex LH-20,column chromatography,and preparative HPLC.Their chemical structures were elucidated on the basis of physicochemical properties and spectra data.Fourteen compounds were isolated and identified as:notoginsenoside R2(1),20(S)-ginsenoside Rg3(2),20(R)-ginsenoside Rg3(3),20(S)-ginsenoside Rg2(4),20(R)-ginsenosideRg2(5),20(S)-ginsenoside Rh1(6),20(R)-ginsenoside Rh1(7),ginsenoside Rh4(8),-Ro(9),-Rb1(10),-Rg1(11),Re-(12),Rf(13),maltol(14).Compounds 1,4,6,were obtained from red ginseng for the first time.Compounds 2 and 3,4 and 5-7 were enantiomers respectively,enantiomers 6 and 7 were isolated as monomer for the first time.

关键词(KeyWords): 红参;化学成分;人参皂苷;结构鉴定
red ginseng;chemical constituents;ginsenoside;structual identification

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基金项目(Foundation): 江苏省公益研究项目(BM2006104)

作者(Author): 刘丹;濮社班;钱士辉;张静岩;
LIU Dan1,2,PU Sheban1*,QIAN Shihui2*,ZHANG Jingyan1,2(1.China Pharmaceutical University,Nanjing 211198,China; 2.Jiangsu Institute of Traditional Chinese Medicine,Nanjing 210028,China)

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